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• W2035035448 abstract "Background context The burst fracture of a vertebra is the result of a complex loading procedure and is often associated with intervertebral disc (IVD) degeneration. Likewise, the presumed etiologies are (i) the structural perturbation of the IVD/end plate, (ii) the impact of loading energy alone, and (iii) the depressurization of the nucleus pulposus. Purpose To describe the pathogenesis of post-traumatic disc degeneration (DD) by comparing the severity and patterns of degeneration with different injury models. Study design New data from an in vitro organ culture study are compared with the previous work on the same model system. Methods To investigate in detail the contribution of each factor (i–iii) to DD, we extended our previous work to compare three different segmental trauma processes in a rabbit full-organ in vitro model: burst fracture (Group A, etiologies i–iii), equienergetic loading without a fracture (Group B, ii), and endplate puncturing (Group C, iii). DD markers (apoptosis, necrosis, matrix remodeling, inflammation) were monitored up to 28 days posttrauma. Gene transcription data were subjected to principal component analysis and agglomerative hierarchical clustering to identify and compare pathologic patterns. Results Only Group A showed the full profile of DD: reduced glycosaminoglycan content, increased caspase-3/7 and lactate dehydrogenase (LDH) activity, and elevated messenger RNA of catabolic (matrix metalloproteinase-1, -3, -13) and proinflammatory (tumor necrosis factor-alpha, interleukin [IL]-6, IL-8, and monocyte chemotactic protein-1) genes. In Group B, only catabolic and proinflammatory genes were slightly upregulated. In Group C, LDH but not caspase-3/7 activity was increased. Catabolic and proinflammatory genes were upregulated, although less compared with Group A. Principal component analysis revealed different transcription patterns for Group C. Conclusions The structural perturbation of the end plate/IVD, but not the loading energy or nuclear depressurization, promotes DD. In addition, end-plate puncturing triggers a different pathogenesis, consistent with a more continuous matrix remodeling process." @default.
• W2035035448 created "2016-06-24" @default.
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• W2035035448 date "2014-07-01" @default.
• W2035035448 modified "2023-09-24" @default.
• W2035035448 title "Severity and pattern of post-traumatic intervertebral disc degeneration depend on the type of injury" @default.
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• W2035035448 doi "https://doi.org/10.1016/j.spinee.2013.07.488" @default.
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