FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035051850> ?p ?o ?g. }

• W2035051850 endingPage "37244" @default.
• W2035051850 startingPage "37233" @default.
• W2035051850 abstract "The expression and functional significance of ryanodine receptors (RyR) were investigated in resting and activated primary human T cells. RyR1, RyR2, and RyR3 transcripts were detected in human T cells. RyR1/2 transcript levels increased, whereas those of RyR3 decreased after T cell activation. RyR1/2 protein immunoreactivity was detected in activated but not in resting T cells. The RyR agonist caffeine evoked Ca(2+) release from the intracellular store in activated T cells but not in resting T cells, indicating that RyR are functionally up-regulated in activated T cells compared with resting T cells. In the presence of store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2+) release-activated Ca(2+) (CRAC) channels, RyR blockers reduced the Ca(2+) leak from the endoplasmic reticulum (ER) and the magnitude of SOCE, suggesting that a positive feedback relationship exists between RyR and CRAC channels. Overexpression of fluorescently tagged RyR2 and stromal interaction molecule 1 (STIM1), an ER Ca(2+) sensor gating CRAC channels, in HEK293 cells revealed that RyR are co-localized with STIM1 in the puncta formed after store depletion. These data indicate that in primary human T cells, the RyR are coupled to CRAC channel machinery such that SOCE activates RyR via a Ca(2+)-induced Ca(2+) release mechanism, which in turn reduces the Ca(2+) concentration within the ER lumen in the vicinity of STIM1, thus facilitating SOCE by reducing store-dependent CRAC channel inactivation. Treatment with RyR blockers suppressed activated T cell expansion, demonstrating the functional importance of RyR in T cells." @default.
• W2035051850 created "2016-06-24" @default.
• W2035051850 creator A5062097208 @default.
• W2035051850 creator A5078668925 @default.
• W2035051850 creator A5090359512 @default.
• W2035051850 date "2012-10-01" @default.
• W2035051850 modified "2023-10-18" @default.
• W2035051850 title "Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes" @default.
• W2035051850 cites W1488869774 @default.
• W2035051850 cites W1491270159 @default.
• W2035051850 cites W1583246305 @default.
• W2035051850 cites W1641967096 @default.
• W2035051850 cites W1700179117 @default.
• W2035051850 cites W1965762685 @default.
• W2035051850 cites W1967565485 @default.
• W2035051850 cites W1974197507 @default.
• W2035051850 cites W1977662916 @default.
• W2035051850 cites W1977795617 @default.
• W2035051850 cites W1978593035 @default.
• W2035051850 cites W1980445622 @default.
• W2035051850 cites W1980633311 @default.
• W2035051850 cites W1983672484 @default.
• W2035051850 cites W1987291967 @default.
• W2035051850 cites W1987878551 @default.
• W2035051850 cites W1988523658 @default.
• W2035051850 cites W1993298907 @default.
• W2035051850 cites W1996411567 @default.
• W2035051850 cites W1997018082 @default.
• W2035051850 cites W2003737587 @default.
• W2035051850 cites W2018447757 @default.
• W2035051850 cites W2019023589 @default.
• W2035051850 cites W2021515748 @default.
• W2035051850 cites W2025596955 @default.
• W2035051850 cites W2030076766 @default.
• W2035051850 cites W2030790147 @default.
• W2035051850 cites W2035138229 @default.
• W2035051850 cites W2039043166 @default.
• W2035051850 cites W2041149807 @default.
• W2035051850 cites W2043458364 @default.
• W2035051850 cites W2047612054 @default.
• W2035051850 cites W2050443418 @default.
• W2035051850 cites W2051231103 @default.
• W2035051850 cites W2055783771 @default.
• W2035051850 cites W2056740334 @default.
• W2035051850 cites W2060201104 @default.
• W2035051850 cites W2063348606 @default.
• W2035051850 cites W2064782766 @default.
• W2035051850 cites W2071089917 @default.
• W2035051850 cites W2076171916 @default.
• W2035051850 cites W2078254067 @default.
• W2035051850 cites W2080492097 @default.
• W2035051850 cites W2081822747 @default.
• W2035051850 cites W2085586163 @default.
• W2035051850 cites W2088371357 @default.
• W2035051850 cites W2090638404 @default.
• W2035051850 cites W2094116513 @default.
• W2035051850 cites W2094401453 @default.
• W2035051850 cites W2097265484 @default.
• W2035051850 cites W2097583263 @default.
• W2035051850 cites W2107748489 @default.
• W2035051850 cites W2109495864 @default.
• W2035051850 cites W2113633128 @default.
• W2035051850 cites W2114570899 @default.
• W2035051850 cites W2117958014 @default.
• W2035051850 cites W2118494007 @default.
• W2035051850 cites W2121230396 @default.
• W2035051850 cites W2124733101 @default.
• W2035051850 cites W2128489958 @default.
• W2035051850 cites W2130597173 @default.
• W2035051850 cites W2131656392 @default.
• W2035051850 cites W2132781656 @default.
• W2035051850 cites W2133926860 @default.
• W2035051850 cites W2136448440 @default.
• W2035051850 cites W2137283585 @default.
• W2035051850 cites W2137407985 @default.
• W2035051850 cites W2139909390 @default.
• W2035051850 cites W2141600581 @default.
• W2035051850 cites W2152467424 @default.
• W2035051850 cites W2160639454 @default.
• W2035051850 cites W2162006028 @default.
• W2035051850 cites W2162909966 @default.
• W2035051850 cites W2164343630 @default.
• W2035051850 cites W2394689413 @default.
• W2035051850 doi "https://doi.org/10.1074/jbc.m112.398974" @default.
• W2035051850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3481322" @default.
• W2035051850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22948152" @default.
• W2035051850 hasPublicationYear "2012" @default.
• W2035051850 type Work @default.
• W2035051850 sameAs 2035051850 @default.
• W2035051850 citedByCount "33" @default.
• W2035051850 countsByYear W20350518502013 @default.
• W2035051850 countsByYear W20350518502014 @default.
• W2035051850 countsByYear W20350518502015 @default.
• W2035051850 countsByYear W20350518502016 @default.
• W2035051850 countsByYear W20350518502017 @default.
• W2035051850 countsByYear W20350518502018 @default.
• W2035051850 countsByYear W20350518502019 @default.
• W2035051850 countsByYear W20350518502020 @default.

• next