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- W2035064544 abstract "Two lathyrane diterpenes (1–2) together with previous ones (3–6) were isolated from Euphorbia lathyris. The structures of 1 and 2 were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques. Stereo configuration and conformation of 1 and 2 were analyzed by X-ray diffraction for the first time. The configuration of the unique isolathyrol diterpene 2 from the seeds of E. Lathyris, was rectified from S∗ to R∗ at C-5. All compounds were examined as modulators of multidrug resistance on MCF-7/ADM cell lines in vitro. Their structure–activity relationship was discussed from aspect of different skeletons. A class of potential P-gp inhibitors with five different types (jokinol, isolathyrol, epoxylathyrol, 7-hydroxylathyrol, lathyrol) was discovered." @default.
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- W2035064544 date "2009-07-01" @default.
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- W2035064544 title "Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures" @default.
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- W2035064544 doi "https://doi.org/10.1016/j.bmc.2009.04.041" @default.
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