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• W2035069260 abstract "BackgroundMathematical modeling can be used to describe the interdependent and dynamic interactions that contribute to the transmission dynamics of vancomycin-resistant enterococci (VRE). A model was developed to quantify the contribution of antibiotic exposure and of other modifiable factors to the dissemination of VRE in the hospital setting MethodsThe model consists of 4 compartments: patients colonized with VRE receiving and not receiving antibiotics and uncolonized patients receiving and not receiving antibiotics. A series of differential equations describe the movement between these compartments. Baseline parameter estimates were obtained from pharmacy, infection-control, and clinical databases ResultsThe main predictions of this model are that (1) preventing the initiation or enhancing the discontinuation of unnecessary antimicrobial therapy will have a greater impact if it is targeted to patients who are not colonized with VRE; (2) increasing the number of patients harboring VRE at the time of hospital admission substantially increases the endemic prevalence of VRE; and (3) eliminating the influx of VRE results in the eradication of this pathogen from the hospital. A decrease in the endemic prevalence of VRE also occurs with a decrease in the length of hospital stay of colonized patients, increased hand hygiene compliance, and a lower ratio of health-care workers:patients ConclusionThis mathematical model provides a framework to assist in targeting necessary interventions aimed at limiting the spread of VRE" @default.
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• W2035069260 date "2005-12-01" @default.
• W2035069260 modified "2023-09-25" @default.
• W2035069260 title "A Mathematical Model Quantifying the Impact of Antibiotic Exposure and Other Interventions on the Endemic Prevalence of Vancomycin‐Resistant Enterococci" @default.
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• W2035069260 doi "https://doi.org/10.1086/498041" @default.
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