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• W2035072057 abstract "Diplomonads are aerotolerant anaerobic, binucleate flagellates, which are commonly found in the intestinal tract of wild and farmed fish. Of the diplomonad genera, Spironucleus, composed of opportunistic pathogens, poses the greatest threat to aquaculture. Immunocompromised hosts or fish without acquired immunity are thought to be more susceptible to parasitism by these otherwise commensal agents. Accumulation of flagellates along the intestinal tract often leads to systemic Spironucleosis causing high mortality of both ornamental and food fish in aquaculture. The life cycle of these piscine diplomonads is direct, consisting of a motile, parasitic trophozoite and a resilient encysted stage, which facilitates water-borne transmission. Confusion in the nomenclature, as well as numerous reassignments of taxa, hampers our understanding of host range and geographical distribution of fish diplomonads. Accurate identification requires transmission electron microscopy to characterise intricate ultrastructural features. Additionally, sequencing of the small subunit ribosomal RNA gene allows identification of cryptic Spironucleus spp. In vitro culture provides a convenient source of flagellates for biochemical and physiological research, allowing the identification of novel parasite-specific molecular pathways such as H2 production within Spironucleus sp. This provides insight into the pathogenicity of these organisms and offers potential new targets for chemotherapy. Restrictions on the administration of the current drug of choice, metronidazole, in aquacultural settings, as well as reported cases of drug resistance, means that control of Spironucleosis is especially difficult. Allium sativum (garlic)-derived compounds have proven highly effective at inhibiting parasite growth in vitro, showing great potential as a novel alternative therapy in the treatment of Spironucleosis. Further characterisation of the biochemistry, pathogenicity and taxonomy of fish diplomonads is required in order to fully appreciate the true impact and economic consequences of Spironucleus spp. in aquaculture." @default.
• W2035072057 created "2016-06-24" @default.
• W2035072057 creator A5019551372 @default.
• W2035072057 creator A5022226245 @default.
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• W2035072057 creator A5035653295 @default.
• W2035072057 creator A5061606031 @default.
• W2035072057 creator A5081329624 @default.
• W2035072057 date "2013-01-01" @default.
• W2035072057 modified "2023-09-29" @default.
• W2035072057 title "Spironucleus species: Economically-Important Fish Pathogens and Enigmatic Single-Celled Eukaryotes" @default.
• W2035072057 cites W102317445 @default.
• W2035072057 cites W1535348278 @default.
• W2035072057 cites W1568570121 @default.
• W2035072057 cites W1583249335 @default.
• W2035072057 cites W1601378624 @default.
• W2035072057 cites W1784167823 @default.
• W2035072057 cites W1804671752 @default.
• W2035072057 cites W1865532149 @default.
• W2035072057 cites W1874928295 @default.
• W2035072057 cites W1920628456 @default.
• W2035072057 cites W1949235286 @default.
• W2035072057 cites W1964400478 @default.
• W2035072057 cites W1969375635 @default.
• W2035072057 cites W1969682850 @default.
• W2035072057 cites W1972562415 @default.
• W2035072057 cites W1973485554 @default.
• W2035072057 cites W1976369679 @default.
• W2035072057 cites W1977625703 @default.
• W2035072057 cites W1980045098 @default.
• W2035072057 cites W1982880625 @default.
• W2035072057 cites W1986049400 @default.
• W2035072057 cites W1986185556 @default.
• W2035072057 cites W1987620662 @default.
• W2035072057 cites W1989330187 @default.
• W2035072057 cites W1995592714 @default.
• W2035072057 cites W1995659918 @default.
• W2035072057 cites W1995672950 @default.
• W2035072057 cites W2002136233 @default.
• W2035072057 cites W2003409294 @default.
• W2035072057 cites W2004023228 @default.
• W2035072057 cites W2007691673 @default.
• W2035072057 cites W2008616641 @default.
• W2035072057 cites W2012540138 @default.
• W2035072057 cites W2015252029 @default.
• W2035072057 cites W2017731049 @default.
• W2035072057 cites W2019477602 @default.
• W2035072057 cites W2020011224 @default.
• W2035072057 cites W2021308572 @default.
• W2035072057 cites W2023603802 @default.
• W2035072057 cites W2027875433 @default.
• W2035072057 cites W2039679883 @default.
• W2035072057 cites W2042543960 @default.
• W2035072057 cites W2046633089 @default.
• W2035072057 cites W2047624021 @default.
• W2035072057 cites W2048360581 @default.
• W2035072057 cites W2049259570 @default.
• W2035072057 cites W2051646016 @default.
• W2035072057 cites W2052574888 @default.
• W2035072057 cites W2055733048 @default.
• W2035072057 cites W2058122434 @default.
• W2035072057 cites W2067773108 @default.
• W2035072057 cites W2070153243 @default.
• W2035072057 cites W2071705016 @default.
• W2035072057 cites W2072063241 @default.
• W2035072057 cites W2074462392 @default.
• W2035072057 cites W2076894226 @default.
• W2035072057 cites W2082102288 @default.
• W2035072057 cites W2082933583 @default.
• W2035072057 cites W2083359532 @default.
• W2035072057 cites W2084653357 @default.
• W2035072057 cites W2087767343 @default.
• W2035072057 cites W2088189751 @default.
• W2035072057 cites W2088647375 @default.
• W2035072057 cites W2091487631 @default.
• W2035072057 cites W2092414822 @default.
• W2035072057 cites W2093100664 @default.
• W2035072057 cites W2093269084 @default.
• W2035072057 cites W2095139198 @default.
• W2035072057 cites W2095519923 @default.
• W2035072057 cites W2096856865 @default.
• W2035072057 cites W2100859710 @default.
• W2035072057 cites W2102979714 @default.
• W2035072057 cites W2111705423 @default.
• W2035072057 cites W2113379835 @default.
• W2035072057 cites W2115787055 @default.
• W2035072057 cites W2123053149 @default.
• W2035072057 cites W2130290417 @default.
• W2035072057 cites W2133421598 @default.
• W2035072057 cites W2133695602 @default.
• W2035072057 cites W2133947518 @default.
• W2035072057 cites W2138175622 @default.
• W2035072057 cites W2141596788 @default.
• W2035072057 cites W2143325902 @default.
• W2035072057 cites W2152378052 @default.
• W2035072057 cites W2152977880 @default.
• W2035072057 cites W2154068115 @default.
• W2035072057 cites W2155030936 @default.
• W2035072057 cites W2157635968 @default.
• W2035072057 cites W2161411518 @default.

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