FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035098976> ?p ?o ?g. }

• W2035098976 endingPage "18271" @default.
• W2035098976 startingPage "18266" @default.
• W2035098976 abstract "A defect in germ-cell (sperm and oocyte) development is the leading cause of male and female infertility. Control of translation through the binding of deleted in azoospermia (DAZ)-like (DAZL) to the 3'-UTRs of mRNAs, via a highly conserved RNA recognition motif (RRM), has been shown to be essential in germ-cell development. Crystal structures of the RRM from murine DAZL (Dazl), both alone and in complex with RNA sequences from the 3'-UTRs of mRNAs regulated by Dazl, reveal high-affinity sequence-specific recognition of a GUU triplet involving an extended, kinked, pair of β-strands. Recognition of the GUU triplet is maintained, whereas the identity and position of bases flanking this triplet varies. The Dazl RRM is thus able to recognize GUU triplets in different sequence contexts. Mutation of bases within the GUU triplet reduces the affinity of binding. Together with the demonstration that multiple Dazl RRMs can bind to a single RNA containing multiple GUU triplets, these structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA. The conservation of RNA binding and structurally important residues between members of the DAZ family, together with the demonstration that mutation of these residues severely impairs RNA binding, indicate that the mode of RNA binding revealed by these structures is conserved in proteins essential for gamete development from flies to humans." @default.
• W2035098976 created "2016-06-24" @default.
• W2035098976 creator A5024108011 @default.
• W2035098976 creator A5028931160 @default.
• W2035098976 creator A5041901473 @default.
• W2035098976 date "2011-10-20" @default.
• W2035098976 modified "2023-09-30" @default.
• W2035098976 title "Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL" @default.
• W2035098976 cites W1645470992 @default.
• W2035098976 cites W1851718298 @default.
• W2035098976 cites W1964641141 @default.
• W2035098976 cites W1967312115 @default.
• W2035098976 cites W1979291624 @default.
• W2035098976 cites W1984065431 @default.
• W2035098976 cites W1985431298 @default.
• W2035098976 cites W1985935590 @default.
• W2035098976 cites W1995581948 @default.
• W2035098976 cites W1997706129 @default.
• W2035098976 cites W2020433571 @default.
• W2035098976 cites W2025701349 @default.
• W2035098976 cites W2031416354 @default.
• W2035098976 cites W2035503835 @default.
• W2035098976 cites W2038747540 @default.
• W2035098976 cites W2044046211 @default.
• W2035098976 cites W2061648581 @default.
• W2035098976 cites W2065651113 @default.
• W2035098976 cites W2071133831 @default.
• W2035098976 cites W2074632084 @default.
• W2035098976 cites W2097846081 @default.
• W2035098976 cites W2100044187 @default.
• W2035098976 cites W2126551891 @default.
• W2035098976 cites W2126934374 @default.
• W2035098976 cites W2127548418 @default.
• W2035098976 cites W2131350133 @default.
• W2035098976 cites W2134850124 @default.
• W2035098976 cites W2144250442 @default.
• W2035098976 cites W2144998676 @default.
• W2035098976 cites W2151478424 @default.
• W2035098976 cites W2151803242 @default.
• W2035098976 cites W2154714625 @default.
• W2035098976 cites W2163341755 @default.
• W2035098976 cites W2166645045 @default.
• W2035098976 cites W2168436056 @default.
• W2035098976 cites W2171569225 @default.
• W2035098976 doi "https://doi.org/10.1073/pnas.1105211108" @default.
• W2035098976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3215079" @default.
• W2035098976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22021443" @default.
• W2035098976 hasPublicationYear "2011" @default.
• W2035098976 type Work @default.
• W2035098976 sameAs 2035098976 @default.
• W2035098976 citedByCount "61" @default.
• W2035098976 countsByYear W20350989762012 @default.
• W2035098976 countsByYear W20350989762013 @default.
• W2035098976 countsByYear W20350989762014 @default.
• W2035098976 countsByYear W20350989762015 @default.
• W2035098976 countsByYear W20350989762016 @default.
• W2035098976 countsByYear W20350989762017 @default.
• W2035098976 countsByYear W20350989762018 @default.
• W2035098976 countsByYear W20350989762019 @default.
• W2035098976 countsByYear W20350989762020 @default.
• W2035098976 countsByYear W20350989762021 @default.
• W2035098976 countsByYear W20350989762022 @default.
• W2035098976 countsByYear W20350989762023 @default.
• W2035098976 crossrefType "journal-article" @default.
• W2035098976 hasAuthorship W2035098976A5024108011 @default.
• W2035098976 hasAuthorship W2035098976A5028931160 @default.
• W2035098976 hasAuthorship W2035098976A5041901473 @default.
• W2035098976 hasBestOaLocation W20350989761 @default.
• W2035098976 hasConcept C104317684 @default.
• W2035098976 hasConcept C105580179 @default.
• W2035098976 hasConcept C149364088 @default.
• W2035098976 hasConcept C153911025 @default.
• W2035098976 hasConcept C158730165 @default.
• W2035098976 hasConcept C2779122487 @default.
• W2035098976 hasConcept C41282012 @default.
• W2035098976 hasConcept C54355233 @default.
• W2035098976 hasConcept C67705224 @default.
• W2035098976 hasConcept C86803240 @default.
• W2035098976 hasConcept C89604277 @default.
• W2035098976 hasConcept C95444343 @default.
• W2035098976 hasConceptScore W2035098976C104317684 @default.
• W2035098976 hasConceptScore W2035098976C105580179 @default.
• W2035098976 hasConceptScore W2035098976C149364088 @default.
• W2035098976 hasConceptScore W2035098976C153911025 @default.
• W2035098976 hasConceptScore W2035098976C158730165 @default.
• W2035098976 hasConceptScore W2035098976C2779122487 @default.
• W2035098976 hasConceptScore W2035098976C41282012 @default.
• W2035098976 hasConceptScore W2035098976C54355233 @default.
• W2035098976 hasConceptScore W2035098976C67705224 @default.
• W2035098976 hasConceptScore W2035098976C86803240 @default.
• W2035098976 hasConceptScore W2035098976C89604277 @default.
• W2035098976 hasConceptScore W2035098976C95444343 @default.
• W2035098976 hasIssue "45" @default.
• W2035098976 hasLocation W20350989761 @default.
• W2035098976 hasLocation W20350989762 @default.
• W2035098976 hasLocation W20350989763 @default.
• W2035098976 hasLocation W20350989764 @default.
• W2035098976 hasOpenAccess W2035098976 @default.

• next