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• W2035103640 startingPage "9514" @default.
• W2035103640 abstract "Thyrotropin-releasing hormone (TRH) is an important extracellular regulatory molecule that functions as a releasing factor in the anterior pituitary gland and as a neurotransmitter/neuromodulator in the central and peripheral nervous systems. Binding sites for TRH are present in these tissues, but the TRH receptor (TRH-R) has not been purified from any source. Using Xenopus laevis oocytes in an expression cloning strategy, we have isolated a cDNA clone that encodes the mouse pituitary TRH-R. This conclusion is based on the following evidence. Injection of sense RNA transcribed in vitro from this cDNA into Xenopus oocytes leads to expression of cell-surface receptors that bind TRH and the competitive antagonist chlordiazepoxide with appropriate affinities and that elicit electrophysiological responses to TRH with the appropriate concentration dependency. Antisense RNA inhibits the TRH response in Xenopus oocytes injected with RNA isolated from normal rat anterior pituitary glands. Finally, transfection of COS-1 cells with this cDNA leads to expression of receptors that bind TRH and chlordiazepoxide with appropriate affinities and that transduce TRH stimulation of inositol phosphate formation. The 3.8-kilobase mouse TRH-R cDNA encodes a protein of 393 amino acids that shows similarities to other guanine nucleotide-binding regulatory protein-coupled receptors." @default.
• W2035103640 created "2016-06-24" @default.
• W2035103640 creator A5005079343 @default.
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• W2035103640 date "1990-12-01" @default.
• W2035103640 modified "2023-10-15" @default.
• W2035103640 title "Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor." @default.
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• W2035103640 doi "https://doi.org/10.1073/pnas.87.24.9514" @default.
• W2035103640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55202" @default.
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