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- W2035127116 abstract "Disseminated intravascular coagulation (DIC) is defined as an exaggerated and systemically occurring activation of coagulation in response to a systemic inflammatory state. The syndrome may complicate a variety of disorders and may lead to serious clinical complications. The characteristic strong systemic activation of blood coagulation in DIC, resulting in the generation and deposition of fibrin in the microvasculature, may be a contributory factor to the development of multi-organ failure. Simultaneously, consumption and subsequent exhaustion of coagulation proteins and platelet may induce severe bleeding complications [ [1] Levi M. Disseminated intravascular coagulation. Crit Care Med. 2007; 35: 2191-2195 Crossref PubMed Scopus (259) Google Scholar ]. Inhibition of the fibrinolytic system further contributes to intravascular clot formation, but in some cases accelerated secondary fibrinolysis may be an important factor in the occurrence of serious bleeding. Hence, a patient with DIC can present with concurrently occurring thrombotic and bleeding problems, which obviously complicates the proper treatment." @default.
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- W2035127116 date "2010-01-01" @default.
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- W2035127116 title "Japanese consensus for disseminated intravascular coagulation (DIC): Is it a small world after all?" @default.
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- W2035127116 doi "https://doi.org/10.1016/j.thromres.2009.08.011" @default.
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