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• W2035134802 endingPage "1603" @default.
• W2035134802 startingPage "1595" @default.
• W2035134802 abstract "The troponin I peptide Nα-acetyl TnI (104–115) amide (TnIp) represents the minimum sequence necessary for inhibition of actomyosin ATPase activity of skeletal muscle (Talbot, J.A. & Hodges, R.S., 1981, J. Biol. Chem. 256, 2798–3802; Van Eyk, J.E. & Hodges, R.S., 1988, J. Biol. Chem. 263, 1726–1732; Van Eyk, J.E., Kay, C.M., & Hodges, R.S., 1991, Biochemistry 30, 9974–9981). In this study, we have used 1H NMR spectroscopy to compare the binding of this inhibitory TnI peptide to a synthetic peptide heterodimer representing site III and site IV of the C-terminal domain of troponin C (TnC) and to calcium-saturated skeletal TnC. The residues whose 1H NMR chemical shifts are perturbed upon TnIp binding are the same in both the site III/site IV heterodimer and TnC. These residues include F102, I104, F112, I113, I121, I149, D150, F151, and F154, which are all found in the C-terminal domain hydrophobic pocket and antiparallel β-sheet region of the synthetic site III/site IV heterodimer and of TnC. Further, the affinity of TnIp binding to the heterodimer (Kd = 192 + 37 μM) was found to be similar to TnIp binding to TnC (48 + 18 μM [Campbell, A.P., Cachia, P.J., & Sykes, B.D., 1991, Biochem. Cell Biol. 69, 674–681]). The results indicate that binding of the inhibitory region of TnI is primarily to the C-terminal domain of TnC. The results also indicate how well the synthetic peptide heterodimer mimics the C-terminal domain of TnC in structure and functional interactions." @default.
• W2035134802 created "2016-06-24" @default.
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• W2035134802 date "1992-12-01" @default.
• W2035134802 modified "2023-10-15" @default.
• W2035134802 title "A¹H NMR study of a ternary peptide complex that mimics the interaction between troponin C and troponin I" @default.
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• W2035134802 doi "https://doi.org/10.1002/pro.5560011207" @default.
• W2035134802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2142143" @default.
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• W2035134802 hasPublicationYear "1992" @default.
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