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- W2035136596 abstract "Nitroglycerin-induced NF-κB activation in trigeminal nucleus caudalis is believed to be partly involved in the pathogenesis of migraine. Atorvastatin, an inhibitor of HMG-CoA reductase, is thought to have pleiotropic effects in various neurologic diseases. Moreover, there are several lines of evidences that atorvastatin inhibits NF-κB activation in peripheral blood mononuclear cells. Thus, this study aims to explore whether atorvastatin attenuates NF-κB activation in trigeminal nucleus caudalis in a nitroglycerin-induced migraine model. A significant increase in nuclear content of p65, an indicator of NF-κB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin. However, the nitroglycerin-induced NF-κB activation in trigeminal nucleus caudalis was attenuated by pretreatment with atorvastatin in a dose-dependent fashion. These results suggest that atorvastatin may be a novel and promising candidate for future treatment or prophylaxis of migraine via attenuating activation of NF-κB in trigeminal nucleus caudalis." @default.
- W2035136596 created "2016-06-24" @default.
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- W2035136596 date "2009-11-01" @default.
- W2035136596 modified "2023-10-17" @default.
- W2035136596 title "Atorvastatin attenuates NF-κB activation in trigeminal nucleus caudalis in a rat model of migraine" @default.
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- W2035136596 doi "https://doi.org/10.1016/j.neulet.2009.08.081" @default.
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