Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035144638> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2035144638 endingPage "239" @default.
- W2035144638 startingPage "232" @default.
- W2035144638 abstract "A 6-month, randomized, double-blind, placebo-controlled study was extended to evaluate long-term safety and efficacy of donepezil in community-dwelling Japanese patients with severe Alzheimer's disease (AD).189 patients were enrolled from the double-blind study into a 52-week, open-label extension study. After a 2- to 8-week washout, donepezil was escalated within 6 weeks to 10 mg/day. Main outcomes were Severe Impairment Battery (SIB), Alzheimer's Disease Cooperative Study-Activities of Daily Living scale for severe AD (ADCS-ADL-sev) and Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). Safety parameters were monitored throughout.Overall, mean change from extension study baseline in SIB scores improved until week 24; however, scores were influenced by prior treatment during the double-blind study and by length of washout. Patients treated with donepezil retained some treatment benefits after a washout of 2-4 weeks but lost all treatment benefits after a washout of 4-8 weeks. There was no change in ADCS-ADL-sev or BEHAVE-AD scores. Adverse events were consistent with the known donepezil safety profile.Donepezil is effective and safe for symptomatic treatment of severe AD for at least 1 year. Patients who receive donepezil 10 mg daily with little or no interruption achieve the best long-term outcome." @default.
- W2035144638 created "2016-06-24" @default.
- W2035144638 creator A5008714689 @default.
- W2035144638 creator A5027434147 @default.
- W2035144638 creator A5028292561 @default.
- W2035144638 creator A5034055017 @default.
- W2035144638 creator A5037410712 @default.
- W2035144638 creator A5051292112 @default.
- W2035144638 creator A5063357446 @default.
- W2035144638 creator A5067266617 @default.
- W2035144638 creator A5074967417 @default.
- W2035144638 creator A5086711499 @default.
- W2035144638 creator A5089320716 @default.
- W2035144638 date "2009-01-01" @default.
- W2035144638 modified "2023-09-23" @default.
- W2035144638 title "Long-Term Safety and Efficacy of Donepezil in Patients with Severe Alzheimer’s Disease: Results from a 52-Week, Open-Label, Multicenter, Extension Study in Japan" @default.
- W2035144638 cites W1704771326 @default.
- W2035144638 cites W1963583371 @default.
- W2035144638 cites W1994753147 @default.
- W2035144638 cites W1996776294 @default.
- W2035144638 cites W2018309238 @default.
- W2035144638 cites W2029183641 @default.
- W2035144638 cites W2045923955 @default.
- W2035144638 cites W2064649894 @default.
- W2035144638 cites W2081285591 @default.
- W2035144638 cites W2112522119 @default.
- W2035144638 cites W2116018809 @default.
- W2035144638 cites W2159011576 @default.
- W2035144638 cites W2193764494 @default.
- W2035144638 cites W51869439 @default.
- W2035144638 doi "https://doi.org/10.1159/000203887" @default.
- W2035144638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19246907" @default.
- W2035144638 hasPublicationYear "2009" @default.
- W2035144638 type Work @default.
- W2035144638 sameAs 2035144638 @default.
- W2035144638 citedByCount "26" @default.
- W2035144638 countsByYear W20351446382013 @default.
- W2035144638 countsByYear W20351446382014 @default.
- W2035144638 countsByYear W20351446382015 @default.
- W2035144638 countsByYear W20351446382016 @default.
- W2035144638 countsByYear W20351446382017 @default.
- W2035144638 countsByYear W20351446382018 @default.
- W2035144638 countsByYear W20351446382021 @default.
- W2035144638 countsByYear W20351446382022 @default.
- W2035144638 crossrefType "journal-article" @default.
- W2035144638 hasAuthorship W2035144638A5008714689 @default.
- W2035144638 hasAuthorship W2035144638A5027434147 @default.
- W2035144638 hasAuthorship W2035144638A5028292561 @default.
- W2035144638 hasAuthorship W2035144638A5034055017 @default.
- W2035144638 hasAuthorship W2035144638A5037410712 @default.
- W2035144638 hasAuthorship W2035144638A5051292112 @default.
- W2035144638 hasAuthorship W2035144638A5063357446 @default.
- W2035144638 hasAuthorship W2035144638A5067266617 @default.
- W2035144638 hasAuthorship W2035144638A5074967417 @default.
- W2035144638 hasAuthorship W2035144638A5086711499 @default.
- W2035144638 hasAuthorship W2035144638A5089320716 @default.
- W2035144638 hasConcept C126322002 @default.
- W2035144638 hasConcept C142724271 @default.
- W2035144638 hasConcept C197934379 @default.
- W2035144638 hasConcept C204787440 @default.
- W2035144638 hasConcept C27081682 @default.
- W2035144638 hasConcept C2779134260 @default.
- W2035144638 hasConcept C2779483572 @default.
- W2035144638 hasConcept C2780904820 @default.
- W2035144638 hasConcept C502032728 @default.
- W2035144638 hasConcept C71924100 @default.
- W2035144638 hasConceptScore W2035144638C126322002 @default.
- W2035144638 hasConceptScore W2035144638C142724271 @default.
- W2035144638 hasConceptScore W2035144638C197934379 @default.
- W2035144638 hasConceptScore W2035144638C204787440 @default.
- W2035144638 hasConceptScore W2035144638C27081682 @default.
- W2035144638 hasConceptScore W2035144638C2779134260 @default.
- W2035144638 hasConceptScore W2035144638C2779483572 @default.
- W2035144638 hasConceptScore W2035144638C2780904820 @default.
- W2035144638 hasConceptScore W2035144638C502032728 @default.
- W2035144638 hasConceptScore W2035144638C71924100 @default.
- W2035144638 hasIssue "3" @default.
- W2035144638 hasLocation W20351446381 @default.
- W2035144638 hasLocation W20351446382 @default.
- W2035144638 hasOpenAccess W2035144638 @default.
- W2035144638 hasPrimaryLocation W20351446381 @default.
- W2035144638 hasRelatedWork W167815567 @default.
- W2035144638 hasRelatedWork W2011091925 @default.
- W2035144638 hasRelatedWork W2028881255 @default.
- W2035144638 hasRelatedWork W2037986700 @default.
- W2035144638 hasRelatedWork W2070434480 @default.
- W2035144638 hasRelatedWork W2124088010 @default.
- W2035144638 hasRelatedWork W2467076809 @default.
- W2035144638 hasRelatedWork W2990530825 @default.
- W2035144638 hasRelatedWork W313460363 @default.
- W2035144638 hasRelatedWork W3168535286 @default.
- W2035144638 hasVolume "27" @default.
- W2035144638 isParatext "false" @default.
- W2035144638 isRetracted "false" @default.
- W2035144638 magId "2035144638" @default.
- W2035144638 workType "article" @default.