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• W2035144764 abstract "Background: Metabolic syndrome (MS) is reported to be highly prevalent in survivors of cancer and allogeneic stem cell transplant (SCT). TBI, chemotherapy, GVHD and it's treatment have been implicated as factors leading to MS after allogeneic SCT.We report preliminary results of the study which is being done with the objectives 1) to estimate the prevalence of MS in children followed at a single US institution; 2) to analyze risk factors associated with the development of MS; and 3) to correlate MS with other endocrine disorders post-SCT.Methods: All patients in the follow-up clinic (>1 year post-SCT) are screened for lipid profile, BP, BMI, waste-hip ratio, microalbuminuria. Diagnosis of MS is based on NCEP-ATPIII criteria. Once diagnosed, patients are retrospectively analyzed regarding demographics, type of SCT, pre-transplant BMI, occurrence and treatment of GVHD, associated endocrine issues. Patients are educated , placed on statins and liver function monitored periodically.Results: 32 patients have been screened till date and 11 (34.3%) diagnosed with MS. The median age is 15 years (11–20 years); 6 female and 5 male. The median duration from SCT to diagnosis was 7.5 years (2.5–14.7 yrs). 7 patients received an allogeneic and 4 an autologous SCT with varied preparative regimens. The median BMI at the time of diagnosis was 22.74 (20.5–36.6). Only 3 (27%) patients were overweight (BMI > 25) at the time of SCT; there was an average BMI increase of 5.5 (0.98–9.4) in the interim between SCT and diagnosis. Hypertriglyceridemia and hypertension were the most common signs of MS. 2 patients have developed overt diabetes and are on insulin. Only 2 patients had history of GVHD treated with steroids. No single factor could be associated with the risk of developing MS, though the number of cases is too small to do risk-factor analysis. 2 patients also had GH deficiency. After diet modification and exercise advise, 7 patients have been placed on Statins and except for 1, all have tolerated it well with no liver dysfunction noted till date (median treatment duration :12 months, range 3–23 months).Conclusions: MS is highly prevalent in pediatric population post -SCT. Both allogeneic and autologous SCT recipients are susceptible and MS is not restricted only to overweight recipients. MS should be suspected, recognized and treated early, as it is a preventable cause of cardio-vascular morbidity and mortality post-SCT. Background: Metabolic syndrome (MS) is reported to be highly prevalent in survivors of cancer and allogeneic stem cell transplant (SCT). TBI, chemotherapy, GVHD and it's treatment have been implicated as factors leading to MS after allogeneic SCT.We report preliminary results of the study which is being done with the objectives 1) to estimate the prevalence of MS in children followed at a single US institution; 2) to analyze risk factors associated with the development of MS; and 3) to correlate MS with other endocrine disorders post-SCT. Methods: All patients in the follow-up clinic (>1 year post-SCT) are screened for lipid profile, BP, BMI, waste-hip ratio, microalbuminuria. Diagnosis of MS is based on NCEP-ATPIII criteria. Once diagnosed, patients are retrospectively analyzed regarding demographics, type of SCT, pre-transplant BMI, occurrence and treatment of GVHD, associated endocrine issues. Patients are educated , placed on statins and liver function monitored periodically. Results: 32 patients have been screened till date and 11 (34.3%) diagnosed with MS. The median age is 15 years (11–20 years); 6 female and 5 male. The median duration from SCT to diagnosis was 7.5 years (2.5–14.7 yrs). 7 patients received an allogeneic and 4 an autologous SCT with varied preparative regimens. The median BMI at the time of diagnosis was 22.74 (20.5–36.6). Only 3 (27%) patients were overweight (BMI > 25) at the time of SCT; there was an average BMI increase of 5.5 (0.98–9.4) in the interim between SCT and diagnosis. Hypertriglyceridemia and hypertension were the most common signs of MS. 2 patients have developed overt diabetes and are on insulin. Only 2 patients had history of GVHD treated with steroids. No single factor could be associated with the risk of developing MS, though the number of cases is too small to do risk-factor analysis. 2 patients also had GH deficiency. After diet modification and exercise advise, 7 patients have been placed on Statins and except for 1, all have tolerated it well with no liver dysfunction noted till date (median treatment duration :12 months, range 3–23 months). Conclusions: MS is highly prevalent in pediatric population post -SCT. Both allogeneic and autologous SCT recipients are susceptible and MS is not restricted only to overweight recipients. MS should be suspected, recognized and treated early, as it is a preventable cause of cardio-vascular morbidity and mortality post-SCT." @default.
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• W2035144764 date "2009-02-01" @default.
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• W2035144764 title "Prevalence, Risk Factors and Management of Metabolic Syndrome After Stem Cell Transplantation In Pediatric Patients" @default.
• W2035144764 doi "https://doi.org/10.1016/j.bbmt.2008.12.248" @default.
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