FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035145240> ?p ?o ?g. }

• W2035145240 endingPage "389" @default.
• W2035145240 startingPage "379" @default.
• W2035145240 abstract "Severe combined immunodeficient (scid) mice engrafted with small pieces of full thickness gut wall from immunocompetent syngenic donors develop a chronic and lethal colitis. Lymphocytes from the lamina propria of engrafted mice were analyzed for phorbol ester/ionomycin-induced cytokine production by intracellular staining. A 4-5-fold increase in the fraction of IFN-gamma-producing CD4+ lamina propria T cells was found in moderately and severely diseased mice when compared to healthy congenic C.B-17 control mice. The number of IL-2-producing T cells was increased by approximately 2-fold when comparing mice suffering from severe disease to healthy control mice. The fraction of TNF-alpha positive CD4+ T cells was increased by a factor of two in both moderately and severely diseased mice. When analyzing Th2 cytokines, it was found that the levels of IL-4-producing CD4+ T cells was not altered in diseased animals, whereas the fraction IL-10-producing CD4+ T cells was reduced by a factor of 20. The combined data showed a 15-25-fold increase in the Th1/Th2 ratio of diseased mice when compared to healthy control mice. No intracellular cytokines could be detected in lymphocytes not treated with phorbol ester/ionomycin. The present data identify a prominent role for Th1-type T helper cells in the immunopathogenesis of gut wall graft-induced inflammatory bowel disease in scid mice." @default.
• W2035145240 created "2016-06-24" @default.
• W2035145240 creator A5059879787 @default.
• W2035145240 creator A5067530823 @default.
• W2035145240 date "1998-01-01" @default.
• W2035145240 modified "2023-10-12" @default.
• W2035145240 title "Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease" @default.
• W2035145240 cites W166805679 @default.
• W2035145240 cites W1964522979 @default.
• W2035145240 cites W1971119469 @default.
• W2035145240 cites W1972922050 @default.
• W2035145240 cites W1972998380 @default.
• W2035145240 cites W1976248974 @default.
• W2035145240 cites W1985440638 @default.
• W2035145240 cites W1989210966 @default.
• W2035145240 cites W1989877475 @default.
• W2035145240 cites W1993946895 @default.
• W2035145240 cites W1997531619 @default.
• W2035145240 cites W1997638368 @default.
• W2035145240 cites W1999272147 @default.
• W2035145240 cites W1999290567 @default.
• W2035145240 cites W2000208875 @default.
• W2035145240 cites W2001536656 @default.
• W2035145240 cites W2002061924 @default.
• W2035145240 cites W2004798666 @default.
• W2035145240 cites W2006655753 @default.
• W2035145240 cites W2010463972 @default.
• W2035145240 cites W2012066742 @default.
• W2035145240 cites W2012528572 @default.
• W2035145240 cites W2013769048 @default.
• W2035145240 cites W2018075167 @default.
• W2035145240 cites W2034204756 @default.
• W2035145240 cites W2036500213 @default.
• W2035145240 cites W2039859865 @default.
• W2035145240 cites W2040512118 @default.
• W2035145240 cites W2041799855 @default.
• W2035145240 cites W2053368973 @default.
• W2035145240 cites W2054698185 @default.
• W2035145240 cites W2055669282 @default.
• W2035145240 cites W2057626594 @default.
• W2035145240 cites W2065022708 @default.
• W2035145240 cites W2068534858 @default.
• W2035145240 cites W2070319044 @default.
• W2035145240 cites W2074978521 @default.
• W2035145240 cites W2075994961 @default.
• W2035145240 cites W2079517510 @default.
• W2035145240 cites W2088809418 @default.
• W2035145240 cites W2108473659 @default.
• W2035145240 cites W2111199584 @default.
• W2035145240 cites W2118202213 @default.
• W2035145240 cites W2124090243 @default.
• W2035145240 cites W2126742810 @default.
• W2035145240 cites W2141672711 @default.
• W2035145240 cites W2160648984 @default.
• W2035145240 cites W2160875559 @default.
• W2035145240 cites W2163943610 @default.
• W2035145240 cites W2166859275 @default.
• W2035145240 cites W2167839623 @default.
• W2035145240 cites W2168524781 @default.
• W2035145240 cites W2173547083 @default.
• W2035145240 cites W2396338222 @default.
• W2035145240 cites W2404854108 @default.
• W2035145240 cites W2480810467 @default.
• W2035145240 cites W4255927153 @default.
• W2035145240 doi "https://doi.org/10.1002/(sici)1521-4141(199801)28:01<379::aid-immu379>3.0.co;2-x" @default.
• W2035145240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9485217" @default.
• W2035145240 hasPublicationYear "1998" @default.
• W2035145240 type Work @default.
• W2035145240 sameAs 2035145240 @default.
• W2035145240 citedByCount "55" @default.
• W2035145240 countsByYear W20351452402013 @default.
• W2035145240 countsByYear W20351452402017 @default.
• W2035145240 countsByYear W20351452402020 @default.
• W2035145240 crossrefType "journal-article" @default.
• W2035145240 hasAuthorship W2035145240A5059879787 @default.
• W2035145240 hasAuthorship W2035145240A5067530823 @default.
• W2035145240 hasBestOaLocation W20351452401 @default.
• W2035145240 hasConcept C203014093 @default.
• W2035145240 hasConcept C2776989580 @default.
• W2035145240 hasConcept C2777310793 @default.
• W2035145240 hasConcept C2778690821 @default.
• W2035145240 hasConcept C529295009 @default.
• W2035145240 hasConcept C54355233 @default.
• W2035145240 hasConcept C79879829 @default.
• W2035145240 hasConcept C86803240 @default.
• W2035145240 hasConcept C95444343 @default.
• W2035145240 hasConceptScore W2035145240C203014093 @default.
• W2035145240 hasConceptScore W2035145240C2776989580 @default.
• W2035145240 hasConceptScore W2035145240C2777310793 @default.
• W2035145240 hasConceptScore W2035145240C2778690821 @default.
• W2035145240 hasConceptScore W2035145240C529295009 @default.
• W2035145240 hasConceptScore W2035145240C54355233 @default.
• W2035145240 hasConceptScore W2035145240C79879829 @default.
• W2035145240 hasConceptScore W2035145240C86803240 @default.
• W2035145240 hasConceptScore W2035145240C95444343 @default.
• W2035145240 hasIssue "1" @default.
• W2035145240 hasLocation W20351452401 @default.
• W2035145240 hasLocation W20351452402 @default.

• next