FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035161796> ?p ?o ?g. }

• W2035161796 abstract "Topoisomerase I (topo I) is a major autoantigen recognized by autoantibodies in about 30% of sera from patients with systemic sclerosis (SSc). Certain HLA-DRB1 and HLA-DQB1 alleles have been reported to be associated with autoantibody and T-cell responses to topo I suggesting a T-cell dependent process. We have examined the MHC class II allele associations with anti-topo I antibodies in 16 patients with SSc compared to 250 healthy controls. Furthermore, we have studied the T cell responses to a recombinant full-length topo I molecule purified from a baculovirus expression system in eight patients with SSc and eight controls (five healthy and three with autoimmune disease). HLA-DR5 was significantly increased in patients with anti-topo I antibodies (P< 0.02). Proliferative peripheral blood mononuclear cell (PBMC) responses to soluble topo I were present in nine of 16 individuals (four of eight with SSc and five of eight controls), including the three SSc patients with anti-topo I antibodies. Homozygosity for HLA DQB1:30:Y alleles was present in five of nine responders (P< 0.03) compared to none of the non-responders. Our findings support the notion that the MHC class II background influences the ability to generate an autoimmune response to intracellular autoantigens to which the immune system may not have been tolerized. Additional factors associated with the generation of autoantibodies appear to be more intimately associated with the development of SSc." @default.
• W2035161796 created "2016-06-24" @default.
• W2035161796 creator A5008535145 @default.
• W2035161796 creator A5010061274 @default.
• W2035161796 creator A5011762967 @default.
• W2035161796 creator A5069660169 @default.
• W2035161796 creator A5071947542 @default.
• W2035161796 date "2000-12-01" @default.
• W2035161796 modified "2023-09-26" @default.
• W2035161796 title "MHC Class II Associations with Autoantibody and T cell Immune Responses to the Scleroderma Autoantigen Topoisomerase I" @default.
• W2035161796 cites W146957296 @default.
• W2035161796 cites W1560479977 @default.
• W2035161796 cites W1596927028 @default.
• W2035161796 cites W1999774067 @default.
• W2035161796 cites W2004836206 @default.
• W2035161796 cites W2013672781 @default.
• W2035161796 cites W2014912378 @default.
• W2035161796 cites W2015669749 @default.
• W2035161796 cites W2027635471 @default.
• W2035161796 cites W2028921539 @default.
• W2035161796 cites W2039714033 @default.
• W2035161796 cites W2055539033 @default.
• W2035161796 cites W2061224389 @default.
• W2035161796 cites W2062193114 @default.
• W2035161796 cites W2063661003 @default.
• W2035161796 cites W2064206677 @default.
• W2035161796 cites W2081028616 @default.
• W2035161796 cites W2088306441 @default.
• W2035161796 cites W2098615002 @default.
• W2035161796 cites W2121359611 @default.
• W2035161796 cites W2133874072 @default.
• W2035161796 cites W2135874742 @default.
• W2035161796 cites W2137082868 @default.
• W2035161796 cites W2137152055 @default.
• W2035161796 cites W2299513640 @default.
• W2035161796 cites W2463057866 @default.
• W2035161796 cites W43621375 @default.
• W2035161796 cites W2624775622 @default.
• W2035161796 doi "https://doi.org/10.1006/jaut.2000.0447" @default.
• W2035161796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11090244" @default.
• W2035161796 hasPublicationYear "2000" @default.
• W2035161796 type Work @default.
• W2035161796 sameAs 2035161796 @default.
• W2035161796 citedByCount "13" @default.
• W2035161796 countsByYear W20351617962012 @default.
• W2035161796 countsByYear W20351617962015 @default.
• W2035161796 countsByYear W20351617962016 @default.
• W2035161796 crossrefType "journal-article" @default.
• W2035161796 hasAuthorship W2035161796A5008535145 @default.
• W2035161796 hasAuthorship W2035161796A5010061274 @default.
• W2035161796 hasAuthorship W2035161796A5011762967 @default.
• W2035161796 hasAuthorship W2035161796A5069660169 @default.
• W2035161796 hasAuthorship W2035161796A5071947542 @default.
• W2035161796 hasConcept C137061746 @default.
• W2035161796 hasConcept C147483822 @default.
• W2035161796 hasConcept C159654299 @default.
• W2035161796 hasConcept C163764329 @default.
• W2035161796 hasConcept C188280979 @default.
• W2035161796 hasConcept C202751555 @default.
• W2035161796 hasConcept C203014093 @default.
• W2035161796 hasConcept C207936829 @default.
• W2035161796 hasConcept C2778814158 @default.
• W2035161796 hasConcept C2779075594 @default.
• W2035161796 hasConcept C2780130043 @default.
• W2035161796 hasConcept C54355233 @default.
• W2035161796 hasConcept C71924100 @default.
• W2035161796 hasConcept C86803240 @default.
• W2035161796 hasConcept C8891405 @default.
• W2035161796 hasConceptScore W2035161796C137061746 @default.
• W2035161796 hasConceptScore W2035161796C147483822 @default.
• W2035161796 hasConceptScore W2035161796C159654299 @default.
• W2035161796 hasConceptScore W2035161796C163764329 @default.
• W2035161796 hasConceptScore W2035161796C188280979 @default.
• W2035161796 hasConceptScore W2035161796C202751555 @default.
• W2035161796 hasConceptScore W2035161796C203014093 @default.
• W2035161796 hasConceptScore W2035161796C207936829 @default.
• W2035161796 hasConceptScore W2035161796C2778814158 @default.
• W2035161796 hasConceptScore W2035161796C2779075594 @default.
• W2035161796 hasConceptScore W2035161796C2780130043 @default.
• W2035161796 hasConceptScore W2035161796C54355233 @default.
• W2035161796 hasConceptScore W2035161796C71924100 @default.
• W2035161796 hasConceptScore W2035161796C86803240 @default.
• W2035161796 hasConceptScore W2035161796C8891405 @default.
• W2035161796 hasLocation W20351617961 @default.
• W2035161796 hasLocation W20351617962 @default.
• W2035161796 hasOpenAccess W2035161796 @default.
• W2035161796 hasPrimaryLocation W20351617961 @default.
• W2035161796 hasRelatedWork W1545402865 @default.
• W2035161796 hasRelatedWork W1913068299 @default.
• W2035161796 hasRelatedWork W1975193462 @default.
• W2035161796 hasRelatedWork W1987891739 @default.
• W2035161796 hasRelatedWork W1994565001 @default.
• W2035161796 hasRelatedWork W2008446843 @default.
• W2035161796 hasRelatedWork W2010943459 @default.
• W2035161796 hasRelatedWork W2059703699 @default.
• W2035161796 hasRelatedWork W2076796594 @default.
• W2035161796 hasRelatedWork W2103233025 @default.
• W2035161796 hasRelatedWork W2107538215 @default.
• W2035161796 hasRelatedWork W2131121772 @default.
• W2035161796 hasRelatedWork W2137082868 @default.

• next