FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035163842> ?p ?o ?g. }

• W2035163842 endingPage "92" @default.
• W2035163842 startingPage "25" @default.
• W2035163842 abstract "The activity of microsomal drug-metabolizing enzymes is altered by several pathological or abnormal physiological states, such as changes in nutritional status, liver, heart or kidney diseases, hormonal disturbances, pregnancy, tumour-bearing state, adjuvant arthritis, changes in reticuloendothelial system and environmental factors (stress, irradiation, heavy metals). The activities of other metabolic pathways, such as glucuronidation, sulphate conjugation, acetylation and alcohol oxidation are generally affected to lesser extents. Rats are most commonly used in drug metabolism studies, and it is important to know that the activity of most of the microsomal drug-metabolizing enzymes is higher in males than in females through androgen action which is readily impaire drug-metabolizing enzymes in male rats are thus manifested by two mechanisms; one is by impairment of androgen action and the other is by depression of the basic enzymic activity. Therefore, those effects of pathological states, observed only in male rats but not in females, are generally not seen in other species of animals, including man. The effects of starvation, hyperthyroidism, adrenal insufficiency, diabetes and morphine administration are cases where changes in metabolism are due solely to impairment of androgen action. In other pathological cases, those drug-metabolizing enzymes showing sex differences are depressed more markedly in male rats than those showing no clear sex difference. The author therefore recommends the use of female rats in the evaluation of the effects of pathological states on hepatic microsomal drug-metabolizing enzymes. Generally, changes in activity of the hepatic enzymes reflect closely the changes in the rates of drug metabolism in vivo. However, the protein-binding of drugs, hepatic blood flow and renal function are also known to affect the rate of drug metabolism and excretion in vivo, and therefore changes of these factors in pathological states should also be taken into consideration." @default.
• W2035163842 created "2016-06-24" @default.
• W2035163842 creator A5007422276 @default.
• W2035163842 date "1977-01-01" @default.
• W2035163842 modified "2023-09-23" @default.
• W2035163842 title "Drug Metabolism under Pathological and Abnormal Physiological States in Animals and Man" @default.
• W2035163842 cites W103175147 @default.
• W2035163842 cites W118132184 @default.
• W2035163842 cites W140672966 @default.
• W2035163842 cites W143941869 @default.
• W2035163842 cites W1480064566 @default.
• W2035163842 cites W1482280407 @default.
• W2035163842 cites W1516246590 @default.
• W2035163842 cites W1522551234 @default.
• W2035163842 cites W1524688136 @default.
• W2035163842 cites W1544027667 @default.
• W2035163842 cites W1550817850 @default.
• W2035163842 cites W1575402562 @default.
• W2035163842 cites W1602537057 @default.
• W2035163842 cites W1650348485 @default.
• W2035163842 cites W167869948 @default.
• W2035163842 cites W1748786300 @default.
• W2035163842 cites W1791785868 @default.
• W2035163842 cites W1855977548 @default.
• W2035163842 cites W1963743829 @default.
• W2035163842 cites W1964479613 @default.
• W2035163842 cites W1964539788 @default.
• W2035163842 cites W1966459654 @default.
• W2035163842 cites W1966561000 @default.
• W2035163842 cites W1967513189 @default.
• W2035163842 cites W1968014478 @default.
• W2035163842 cites W1968030616 @default.
• W2035163842 cites W1969168847 @default.
• W2035163842 cites W1969347671 @default.
• W2035163842 cites W1969652105 @default.
• W2035163842 cites W1969775398 @default.
• W2035163842 cites W1969940350 @default.
• W2035163842 cites W1970701023 @default.
• W2035163842 cites W1975795345 @default.
• W2035163842 cites W1975926506 @default.
• W2035163842 cites W1978059889 @default.
• W2035163842 cites W1978109120 @default.
• W2035163842 cites W1978169298 @default.
• W2035163842 cites W1978440467 @default.
• W2035163842 cites W1979137390 @default.
• W2035163842 cites W1979884342 @default.
• W2035163842 cites W1980303953 @default.
• W2035163842 cites W1980656012 @default.
• W2035163842 cites W1980857267 @default.
• W2035163842 cites W1981292392 @default.
• W2035163842 cites W1983031892 @default.
• W2035163842 cites W1983343524 @default.
• W2035163842 cites W1983490988 @default.
• W2035163842 cites W1983574893 @default.
• W2035163842 cites W1984096048 @default.
• W2035163842 cites W1985904589 @default.
• W2035163842 cites W1986305437 @default.
• W2035163842 cites W1986488725 @default.
• W2035163842 cites W1986961385 @default.
• W2035163842 cites W1987207294 @default.
• W2035163842 cites W1988295139 @default.
• W2035163842 cites W1989447870 @default.
• W2035163842 cites W1989583516 @default.
• W2035163842 cites W1992352552 @default.
• W2035163842 cites W1992571095 @default.
• W2035163842 cites W1993093128 @default.
• W2035163842 cites W1993400771 @default.
• W2035163842 cites W1993915641 @default.
• W2035163842 cites W1994161331 @default.
• W2035163842 cites W1994341238 @default.
• W2035163842 cites W1994772737 @default.
• W2035163842 cites W199630055 @default.
• W2035163842 cites W1998033119 @default.
• W2035163842 cites W1998173175 @default.
• W2035163842 cites W1998448857 @default.
• W2035163842 cites W1999012807 @default.
• W2035163842 cites W1999074460 @default.
• W2035163842 cites W2000297898 @default.
• W2035163842 cites W2000755161 @default.
• W2035163842 cites W2002115573 @default.
• W2035163842 cites W2002194276 @default.
• W2035163842 cites W2003023094 @default.
• W2035163842 cites W2003160471 @default.
• W2035163842 cites W2003250793 @default.
• W2035163842 cites W200350134 @default.
• W2035163842 cites W2003630271 @default.
• W2035163842 cites W2003961814 @default.
• W2035163842 cites W2007192956 @default.
• W2035163842 cites W2007423865 @default.
• W2035163842 cites W2009789708 @default.
• W2035163842 cites W2010904013 @default.
• W2035163842 cites W2011630277 @default.
• W2035163842 cites W2012141631 @default.
• W2035163842 cites W2012738024 @default.
• W2035163842 cites W2013320159 @default.
• W2035163842 cites W2013510399 @default.
• W2035163842 cites W2014249212 @default.
• W2035163842 cites W2015011671 @default.

• next