Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035164059> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2035164059 endingPage "S223" @default.
- W2035164059 startingPage "S214" @default.
- W2035164059 abstract "Suitable antibacterial levels were achieved in sera of newborn infants following individual doses of gentamicin of 1.5–2.5 mg/kg given every 8 or 12 hr. The larger dose gave more predictable levels within the desired therapeutic range, and the highest individual level in serum was below the known toxic range. Significant accumulation was not observed with multiple doses for up to 12 days of therapy. Levels in serum and half-life values after intravenous infusion of gentamicin over a 2-hr period were similar to those after intramuscular administration. Excretion was primarily by glomerular filtration and correlated better with postnatal age than with body weight. Gentamicin was detectable in cerebrospinal fluid following intramuscular administration. The level in spinal fluid was dependent on dose, time after administration, and degree of meningeal inflammation. Intrathecal instillation resulted in higher levels in spinal fluid. The efficacy of gentamicin was evaluated in 81 neonatal infants. Fifty-five infants responded promptly, 20 infants responded moderately well, and a poor response was observed in six infants. There was no evidence of acute hematologic or renal toxicity in the 74 infants studied." @default.
- W2035164059 created "2016-06-24" @default.
- W2035164059 creator A5010947152 @default.
- W2035164059 creator A5017411732 @default.
- W2035164059 creator A5048556731 @default.
- W2035164059 date "1971-12-01" @default.
- W2035164059 modified "2023-09-27" @default.
- W2035164059 title "Pharmacologic Evaluation of Gentamicin in Newborn Infants" @default.
- W2035164059 cites W1979575444 @default.
- W2035164059 cites W1982394262 @default.
- W2035164059 cites W1996702235 @default.
- W2035164059 cites W2029517388 @default.
- W2035164059 cites W2106050249 @default.
- W2035164059 cites W2170457690 @default.
- W2035164059 cites W2325379851 @default.
- W2035164059 cites W2331851671 @default.
- W2035164059 cites W2333872340 @default.
- W2035164059 cites W2441223274 @default.
- W2035164059 doi "https://doi.org/10.1093/infdis/124.supplement_1.s214" @default.
- W2035164059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4942331" @default.
- W2035164059 hasPublicationYear "1971" @default.
- W2035164059 type Work @default.
- W2035164059 sameAs 2035164059 @default.
- W2035164059 citedByCount "70" @default.
- W2035164059 countsByYear W20351640592012 @default.
- W2035164059 countsByYear W20351640592013 @default.
- W2035164059 countsByYear W20351640592014 @default.
- W2035164059 crossrefType "journal-article" @default.
- W2035164059 hasAuthorship W2035164059A5010947152 @default.
- W2035164059 hasAuthorship W2035164059A5017411732 @default.
- W2035164059 hasAuthorship W2035164059A5048556731 @default.
- W2035164059 hasConcept C10146269 @default.
- W2035164059 hasConcept C126322002 @default.
- W2035164059 hasConcept C2775832221 @default.
- W2035164059 hasConcept C2776291583 @default.
- W2035164059 hasConcept C2777787772 @default.
- W2035164059 hasConcept C2779651940 @default.
- W2035164059 hasConcept C2780026642 @default.
- W2035164059 hasConcept C29730261 @default.
- W2035164059 hasConcept C42219234 @default.
- W2035164059 hasConcept C42407357 @default.
- W2035164059 hasConcept C501593827 @default.
- W2035164059 hasConcept C71924100 @default.
- W2035164059 hasConcept C86803240 @default.
- W2035164059 hasConcept C89423630 @default.
- W2035164059 hasConceptScore W2035164059C10146269 @default.
- W2035164059 hasConceptScore W2035164059C126322002 @default.
- W2035164059 hasConceptScore W2035164059C2775832221 @default.
- W2035164059 hasConceptScore W2035164059C2776291583 @default.
- W2035164059 hasConceptScore W2035164059C2777787772 @default.
- W2035164059 hasConceptScore W2035164059C2779651940 @default.
- W2035164059 hasConceptScore W2035164059C2780026642 @default.
- W2035164059 hasConceptScore W2035164059C29730261 @default.
- W2035164059 hasConceptScore W2035164059C42219234 @default.
- W2035164059 hasConceptScore W2035164059C42407357 @default.
- W2035164059 hasConceptScore W2035164059C501593827 @default.
- W2035164059 hasConceptScore W2035164059C71924100 @default.
- W2035164059 hasConceptScore W2035164059C86803240 @default.
- W2035164059 hasConceptScore W2035164059C89423630 @default.
- W2035164059 hasIssue "Supplement 1" @default.
- W2035164059 hasLocation W20351640591 @default.
- W2035164059 hasLocation W20351640592 @default.
- W2035164059 hasOpenAccess W2035164059 @default.
- W2035164059 hasPrimaryLocation W20351640591 @default.
- W2035164059 hasRelatedWork W1535976727 @default.
- W2035164059 hasRelatedWork W2028744327 @default.
- W2035164059 hasRelatedWork W2037661912 @default.
- W2035164059 hasRelatedWork W2062391036 @default.
- W2035164059 hasRelatedWork W2091822571 @default.
- W2035164059 hasRelatedWork W2140066901 @default.
- W2035164059 hasRelatedWork W2323497626 @default.
- W2035164059 hasRelatedWork W2402896172 @default.
- W2035164059 hasRelatedWork W2413357943 @default.
- W2035164059 hasRelatedWork W2467273834 @default.
- W2035164059 hasVolume "124" @default.
- W2035164059 isParatext "false" @default.
- W2035164059 isRetracted "false" @default.
- W2035164059 magId "2035164059" @default.
- W2035164059 workType "article" @default.