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• W2035166632 abstract "You have accessJournal of UrologyProstate Cancer: Localized VII1 Apr 2014MP62-04 DOES AGE REPRESENT A LIMITATION FOR HIFU TREATMENT? AGE STRATIFIED OUTCOMES FROM A MULTICENTRE STUDY OF 2762 PATIENTS ANALYSED FROM THE @-REGISTRY Sebastien Crouzet, Roman Ganzer, Stefan Thueroff, Andreas Blana, Christian Chaussy, and Albert Gelet Sebastien CrouzetSebastien Crouzet More articles by this author , Roman GanzerRoman Ganzer More articles by this author , Stefan ThueroffStefan Thueroff More articles by this author , Andreas BlanaAndreas Blana More articles by this author , Christian ChaussyChristian Chaussy More articles by this author , and Albert GeletAlbert Gelet More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1961AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High intensity focused ultrasound (HIFU) performed by Ablatherm® has been used as primary treatment of localized prostate cancer. In the last years, HIFU has been recognized as a therapeutic option in patients over 70 years old with 10 years life expectancy. The objective of this study is to report the biochemical and biopsy outcomes, stratified by age, in patients who have undergone HIFU. METHODS A total of 2762 consecutive patients with T1-T2 prostate cancer treated by HIFU Ablatherm® (EDAP-TMS, Lyon, France), in three European HIFU centers since 1993 were included. Treatment results, and post treatment morbidity have been registered in the online Ablatherm® HIFU database, @-Registry. This is a secured on-line database collecting relevant de-identified clinical and technical information for patients treated by HIFU. Patients were stratified by age into two groups: below 70 years (n=1359) and above 70 years (n=1403) and stratified according to D’Amico’s 2003 risk group definitions. Kaplan-Meier analysis was performed to determine biochemical survival with failure defined according to the 2006 Phoenix definition (nadir+2). Biopsy data were also analyzed. RESULTS In the group above 70 years, the median PSA and the mean Gleason score were higher than in the group below 70 years: 8.0ng/ml vs 7.2ng/ml (p<0.001) and 5.8±1.2 vs 6.2±1.2 (p<0.001). No significant difference was observed between the two groups for clinical stage (p=0.232) and previous androgen deprivation (25% vs 25%), (p=0.728). The mean follow-up was 5.0 ±4 years (median 4.5). The PSA nadir was similar in the two groups: 0.79±3.3 (median 0.10) vs 0.81±2.4 (median 0.10) (p=0.851). The negative biopsy rates (<70 yrs / >70yrs) were 74.6% and 72.9% (p=0.619). The actuarial biochemical disease free survival at 5 years (<70 yrs / >70yrs) was 84% and 78% (p<0.001). At 10 years the overall survival rates (<70 yrs / >70yrs) was significantly different: 85% /74% (p<0.0001), but the cancer specific survival and the metastasis free survival rates (<70 yrs / >70yrs) were not significantly different: 98%/98% (p=0.975) and 94%/94% (p=0.784). CONCLUSIONS HIFU presents positive oncological and functional outcome in patients both below and above 70 years. HIFU treatment might be therefore a valuable therapeutic option for prostate cancer control regardless of age. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e718 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Sebastien Crouzet More articles by this author Roman Ganzer More articles by this author Stefan Thueroff More articles by this author Andreas Blana More articles by this author Christian Chaussy More articles by this author Albert Gelet More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ..." @default.
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• W2035166632 title "MP62-04 DOES AGE REPRESENT A LIMITATION FOR HIFU TREATMENT? AGE STRATIFIED OUTCOMES FROM A MULTICENTRE STUDY OF 2762 PATIENTS ANALYSED FROM THE @-REGISTRY" @default.
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