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• W2035168434 abstract "The role of the ATP-sensitive K⁺ channel (I_K,ATP in the development of A-V block during hypoxic interventions was studied using Langendorff perfused rabbit hearts multicellular rabbit A-V nodal preparations and single quinea-pig ventricular myocytes. With the Langendorff perfused hearts, hypoxic perfusion (PO₂≑40 mmHg) for 30 min caused slowing of the sinus rate and prolongaton of the A-H interval without the appearance of the blocked beats. Substrate-free hypoxic perfusion induced second ot third degree A-V block in 8/10 hearts and substrate-free hypoxic perfusion plus 2-deoxyglucose (5mm) produced third degree A-V block in 6/6 preparations. Addition of 50 mm glucose in the perfusate restored A-V conduction during hypoxic intervention. Application of glibenclamide, a specific bloker of I_KATP, prevented the development of second or third degree A-V block during substrate-free hypoxia (n=6), whereas pinacidil, an opener of I_KATP, caused development of third degree A-V block during hypoxia (n=9). Application of theophylline (100_μM) did not prevent the development of advanced degrees of A-V block during hypotic interventions. In multocellular A-V nodal preparations. 10_μM glibenclamide prevented the shortening of the action potential duration and block development without marked effects on the maximum upstroke velocity of the action potentials during hypoxic intervention. In isolated ventricular myocytes studied by the patchclamp method, the substrate-free hypoxia plus 2-deoxyglucose included the openings of I_KATP in 9/25 preparations with cell-attached patches, while 2/20 patches exhibited sporadic channel openings in the normoxic condition during comparable observation period. The results suggest that openings of the ATP-sensitive K⁺ channels play a role in the development and aggravation of advanced A-V block during hypoxic interventions." @default.
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• W2035168434 date "1995-01-01" @default.
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• W2035168434 title "Role for ATP-sensitive K+ channel in the development of A-V block during hypoxia" @default.
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• W2035168434 doi "https://doi.org/10.1016/s0022-2828(08)80057-0" @default.
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