Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035168907> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2035168907 endingPage "159" @default.
- W2035168907 startingPage "153" @default.
- W2035168907 abstract "Human immunodeficiency virus infection is associated with declining immune function and polyclonal B-cell activation leading to elevated IgE-levels. In selected patient categories, increased total IgE may be associated with allergic diseases. Furthermore, a significant number of patients with low CD4+ cell numbers have various skin manifestations, eg, eczema and dermatophytosis. Patients with chronic fungal infections and a tendency to produce increased levels of specific IgE may become allergic and IgE-mediated mechanism may contribute to inflammatory reactions in the skin.This study investigates IgE-sensitization of patients infected with human immunodeficiency virus to a panel of fungal extracts of Candida albicans, Fusarium moniliforme, Penicillium notatum, Pityrosporum ovale, and Trichophyton rubrum.Fifteen HIV-positive patients with eczematous skin manifestations and five non-atopic healthy controls were evaluated by basophil histamine release and skin prick test with fungal extracts. The extracts were separated by sodium dodecylsulfate-polyacrylamide gel electrophoresis under reducing conditions and analyzed by IgE-immunoblotting with sera from the patients and controls.Thirteen of 15 patients (87%) released histamine to one or more of the fungi. Skin prick test was positive to one or more fungi in 7 (47%) patients. Patient sera revealed binding to a wide range of IgE-binding components present in the fungal extracts. The IgE response was most often directed against a 46-kD main protein in the Candida albicans extract. There was no correlation between total serum IgE, CD4+ cell counts, and frequency of IgE-sensitization to fungi.The human IgE response in HIV-infected patients appears to be polyspecific and may be directed against various fungi of which Candida albicans may be an important allergen. It is possible that the sensitization is due to frequent infections with Candida albicans in this patient population. No unspecific fungal reactions were noted among control patients. These results suggest that allergen-specific IgE-mediated mechanism may contribute to the pathogenesis of the eczematous skin reaction in HIV-infected patients." @default.
- W2035168907 created "2016-06-24" @default.
- W2035168907 creator A5015059913 @default.
- W2035168907 creator A5020536630 @default.
- W2035168907 creator A5020867814 @default.
- W2035168907 creator A5034396313 @default.
- W2035168907 creator A5052563874 @default.
- W2035168907 creator A5056347459 @default.
- W2035168907 date "1999-08-01" @default.
- W2035168907 modified "2023-10-18" @default.
- W2035168907 title "Evaluation of IgE-sensitization to fungi in HIV-positive patients with eczematous skin reactions" @default.
- W2035168907 cites W1499836599 @default.
- W2035168907 cites W1970356423 @default.
- W2035168907 cites W1980130989 @default.
- W2035168907 cites W1990677029 @default.
- W2035168907 cites W1996708476 @default.
- W2035168907 cites W2001457413 @default.
- W2035168907 cites W2011602902 @default.
- W2035168907 cites W2016758648 @default.
- W2035168907 cites W2029088672 @default.
- W2035168907 cites W2030002258 @default.
- W2035168907 cites W2033211204 @default.
- W2035168907 cites W2040206279 @default.
- W2035168907 cites W2080420848 @default.
- W2035168907 cites W2084585806 @default.
- W2035168907 cites W2100837269 @default.
- W2035168907 cites W2114035480 @default.
- W2035168907 cites W2122434713 @default.
- W2035168907 cites W2129215337 @default.
- W2035168907 cites W2154818679 @default.
- W2035168907 cites W2156921672 @default.
- W2035168907 cites W2411700313 @default.
- W2035168907 doi "https://doi.org/10.1016/s1081-1206(10)62628-2" @default.
- W2035168907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10480590" @default.
- W2035168907 hasPublicationYear "1999" @default.
- W2035168907 type Work @default.
- W2035168907 sameAs 2035168907 @default.
- W2035168907 citedByCount "8" @default.
- W2035168907 countsByYear W20351689072016 @default.
- W2035168907 countsByYear W20351689072021 @default.
- W2035168907 crossrefType "journal-article" @default.
- W2035168907 hasAuthorship W2035168907A5015059913 @default.
- W2035168907 hasAuthorship W2035168907A5020536630 @default.
- W2035168907 hasAuthorship W2035168907A5020867814 @default.
- W2035168907 hasAuthorship W2035168907A5034396313 @default.
- W2035168907 hasAuthorship W2035168907A5052563874 @default.
- W2035168907 hasAuthorship W2035168907A5056347459 @default.
- W2035168907 hasConcept C1122143 @default.
- W2035168907 hasConcept C126322002 @default.
- W2035168907 hasConcept C141105273 @default.
- W2035168907 hasConcept C159654299 @default.
- W2035168907 hasConcept C203014093 @default.
- W2035168907 hasConcept C207480886 @default.
- W2035168907 hasConcept C2776217527 @default.
- W2035168907 hasConcept C2777697326 @default.
- W2035168907 hasConcept C2778329239 @default.
- W2035168907 hasConcept C2780451875 @default.
- W2035168907 hasConcept C2780917455 @default.
- W2035168907 hasConcept C71924100 @default.
- W2035168907 hasConcept C86803240 @default.
- W2035168907 hasConcept C89423630 @default.
- W2035168907 hasConceptScore W2035168907C1122143 @default.
- W2035168907 hasConceptScore W2035168907C126322002 @default.
- W2035168907 hasConceptScore W2035168907C141105273 @default.
- W2035168907 hasConceptScore W2035168907C159654299 @default.
- W2035168907 hasConceptScore W2035168907C203014093 @default.
- W2035168907 hasConceptScore W2035168907C207480886 @default.
- W2035168907 hasConceptScore W2035168907C2776217527 @default.
- W2035168907 hasConceptScore W2035168907C2777697326 @default.
- W2035168907 hasConceptScore W2035168907C2778329239 @default.
- W2035168907 hasConceptScore W2035168907C2780451875 @default.
- W2035168907 hasConceptScore W2035168907C2780917455 @default.
- W2035168907 hasConceptScore W2035168907C71924100 @default.
- W2035168907 hasConceptScore W2035168907C86803240 @default.
- W2035168907 hasConceptScore W2035168907C89423630 @default.
- W2035168907 hasIssue "2" @default.
- W2035168907 hasLocation W20351689071 @default.
- W2035168907 hasLocation W20351689072 @default.
- W2035168907 hasOpenAccess W2035168907 @default.
- W2035168907 hasPrimaryLocation W20351689071 @default.
- W2035168907 hasRelatedWork W2021494707 @default.
- W2035168907 hasRelatedWork W2028085943 @default.
- W2035168907 hasRelatedWork W2032297797 @default.
- W2035168907 hasRelatedWork W2098164544 @default.
- W2035168907 hasRelatedWork W2115366376 @default.
- W2035168907 hasRelatedWork W2405856679 @default.
- W2035168907 hasRelatedWork W2408190872 @default.
- W2035168907 hasRelatedWork W2411558284 @default.
- W2035168907 hasRelatedWork W2434524692 @default.
- W2035168907 hasRelatedWork W4383813083 @default.
- W2035168907 hasVolume "83" @default.
- W2035168907 isParatext "false" @default.
- W2035168907 isRetracted "false" @default.
- W2035168907 magId "2035168907" @default.
- W2035168907 workType "article" @default.