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• W2035177789 startingPage "1087" @default.
• W2035177789 abstract "Codon usage bias (CUB) is the well known phenomenon that the frequency of synonymous codons is unequal. This is presumably the result of adaptive pressures favouring some codons over others. The underlying reason for this pressure is unknown, although a large number of possible driver mechanisms have been proposed; one of them is the decoding time. The standard model to calculate decoding time is the Gromadski-Rodnina model. Yet, recently, there have been a number of studies arguing to the effect that this conventional speed-model is not relevant to understand the dynamics of translation. However, results remain inconclusive so far. This contribution takes a novel approach to address this issue based on comparing mRNA with random synonymous variants to estimate the evolutionary pressures that have acted on the transcriptome. It emerges that over 70 percent of ORFs have been subject to a strong selection pressure for translation speed and that there is also a strong selection pressure for the avoidance of traffic jams. Finally, it is also shown that both homogeneous and very heterogeneous transcripts are over-represented. These results corroborate the validity of the Gromadski-Rodnina model." @default.
• W2035177789 created "2016-06-24" @default.
• W2035177789 creator A5013550266 @default.
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• W2035177789 date "2015-09-01" @default.
• W2035177789 modified "2023-09-23" @default.
• W2035177789 title "Evolutionary Pressures on the Yeast Transcriptome" @default.
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• W2035177789 doi "https://doi.org/10.1109/tcbb.2015.2420554" @default.
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• W2035177789 hasPublicationYear "2015" @default.
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