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- W2035191164 abstract "We studied the effect of staurosporine, a potent inhibitor of protein kinase C (PKC) activity, on the phorbol ester- or monoclonal antibody (mAb)-induced modulation of CD3 and CD4 surface antigens. Staurosporine (10(-5) M) completely inhibited phorbol ester-induced modulation but had no effect on that induced by mAb. These results indicate that the down-regulation of CD3 and CD4 observed after activation of the cells by the corresponding mAb is independent from PKC-mediated phosphorylations, and thus that the activation of PKC is sufficient but not necessary to induce the modulation of CD3 and CD4 antigens." @default.
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- W2035191164 date "1990-05-01" @default.
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- W2035191164 title "The activation of protein kinase C is not necessary for the monoclonalantibody-induced modulation of CD3 and CD4 antigens" @default.
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- W2035191164 doi "https://doi.org/10.1002/eji.1830200539" @default.
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