FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035202357> ?p ?o ?g. }

• W2035202357 endingPage "665" @default.
• W2035202357 startingPage "659" @default.
• W2035202357 abstract "ObjectiveTo determine the relationship between uterine bleeding patterns in levonorgestrel users with endometrial histology and expression of interleukins (IL) IL-13 and IL-15.DesignProspective observational study.SettingAcademic research center.Patient(s)Questionnaires were sent to patients (n = 578) who had levonorgestrel implants concerning bleeding patterns; 35 of these patients were identified to have regular cycle (n = 13), amenorrhea (n = 8), or metrorrhagia (n = 14).Intervention(s)Endometrial biopsies, serum, histology, and immunostaining.Main outcome measure(s)Endometrial histological assessment and immunostaining for IL-13 and IL-15 and for blood levonorgestrel, E2, and progesterone levels by ELISA or RIA.Result(s)No correlation was found between circulating levonorgestrel, E2, or progesterone levels with the bleeding patterns, although a trend toward a lower E2 level was observed in patients with amenorrhea who had inactive endometrium. There was a direct correlation between bleeding patterns and endometrial histology, as well as IL-13 and IL-15 expression in patients with regular cycles and metrorrhagia, demonstrating secretory and proliferative endometrium, respectively. Some patients in each group were also identified as demonstrating endometritis.Conclusion(s)Endometrial histology may assist directing therapy and subsequently increasing compliance in progestin-only contraceptive users with irregular bleeding who fail to respond to standard therapies. Altered endometrial expression of IL-13 and IL-15, key cytokines in inflammatory and immune cell trafficking, may influence events, leading to irregular bleeding. To determine the relationship between uterine bleeding patterns in levonorgestrel users with endometrial histology and expression of interleukins (IL) IL-13 and IL-15. Prospective observational study. Academic research center. Questionnaires were sent to patients (n = 578) who had levonorgestrel implants concerning bleeding patterns; 35 of these patients were identified to have regular cycle (n = 13), amenorrhea (n = 8), or metrorrhagia (n = 14). Endometrial biopsies, serum, histology, and immunostaining. Endometrial histological assessment and immunostaining for IL-13 and IL-15 and for blood levonorgestrel, E2, and progesterone levels by ELISA or RIA. No correlation was found between circulating levonorgestrel, E2, or progesterone levels with the bleeding patterns, although a trend toward a lower E2 level was observed in patients with amenorrhea who had inactive endometrium. There was a direct correlation between bleeding patterns and endometrial histology, as well as IL-13 and IL-15 expression in patients with regular cycles and metrorrhagia, demonstrating secretory and proliferative endometrium, respectively. Some patients in each group were also identified as demonstrating endometritis. Endometrial histology may assist directing therapy and subsequently increasing compliance in progestin-only contraceptive users with irregular bleeding who fail to respond to standard therapies. Altered endometrial expression of IL-13 and IL-15, key cytokines in inflammatory and immune cell trafficking, may influence events, leading to irregular bleeding." @default.
• W2035202357 created "2016-06-24" @default.
• W2035202357 creator A5024369252 @default.
• W2035202357 creator A5031138425 @default.
• W2035202357 creator A5061058041 @default.
• W2035202357 creator A5083302653 @default.
• W2035202357 date "2005-03-01" @default.
• W2035202357 modified "2023-10-17" @default.
• W2035202357 title "Histological characteristics and altered expression of interleukins (IL) IL-13 and IL-15 in endometria of levonorgestrel users with different uterine bleeding patterns" @default.
• W2035202357 cites W110118653 @default.
• W2035202357 cites W1974150229 @default.
• W2035202357 cites W1974373140 @default.
• W2035202357 cites W1975176092 @default.
• W2035202357 cites W1986793572 @default.
• W2035202357 cites W1989950888 @default.
• W2035202357 cites W2005196054 @default.
• W2035202357 cites W2007026627 @default.
• W2035202357 cites W2015652509 @default.
• W2035202357 cites W2026745841 @default.
• W2035202357 cites W2032106677 @default.
• W2035202357 cites W2042397706 @default.
• W2035202357 cites W2050827330 @default.
• W2035202357 cites W2055584089 @default.
• W2035202357 cites W2069236182 @default.
• W2035202357 cites W2078703066 @default.
• W2035202357 cites W2082526193 @default.
• W2035202357 cites W2085809186 @default.
• W2035202357 cites W2090262871 @default.
• W2035202357 cites W2090838521 @default.
• W2035202357 cites W2121936089 @default.
• W2035202357 cites W2139020336 @default.
• W2035202357 cites W2139056292 @default.
• W2035202357 cites W2144750345 @default.
• W2035202357 cites W2262444131 @default.
• W2035202357 doi "https://doi.org/10.1016/j.fertnstert.2004.11.009" @default.
• W2035202357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15749495" @default.
• W2035202357 hasPublicationYear "2005" @default.
• W2035202357 type Work @default.
• W2035202357 sameAs 2035202357 @default.
• W2035202357 citedByCount "21" @default.
• W2035202357 countsByYear W20352023572014 @default.
• W2035202357 countsByYear W20352023572016 @default.
• W2035202357 crossrefType "journal-article" @default.
• W2035202357 hasAuthorship W2035202357A5024369252 @default.
• W2035202357 hasAuthorship W2035202357A5031138425 @default.
• W2035202357 hasAuthorship W2035202357A5061058041 @default.
• W2035202357 hasAuthorship W2035202357A5083302653 @default.
• W2035202357 hasBestOaLocation W20352023571 @default.
• W2035202357 hasConcept C126322002 @default.
• W2035202357 hasConcept C134018914 @default.
• W2035202357 hasConcept C2776607906 @default.
• W2035202357 hasConcept C2777164284 @default.
• W2035202357 hasConcept C2777687323 @default.
• W2035202357 hasConcept C2777902738 @default.
• W2035202357 hasConcept C2778058571 @default.
• W2035202357 hasConcept C2779058012 @default.
• W2035202357 hasConcept C2779076696 @default.
• W2035202357 hasConcept C2779234561 @default.
• W2035202357 hasConcept C2779742232 @default.
• W2035202357 hasConcept C2780186607 @default.
• W2035202357 hasConcept C2908647359 @default.
• W2035202357 hasConcept C29456083 @default.
• W2035202357 hasConcept C2986817661 @default.
• W2035202357 hasConcept C54355233 @default.
• W2035202357 hasConcept C57742111 @default.
• W2035202357 hasConcept C71315377 @default.
• W2035202357 hasConcept C71924100 @default.
• W2035202357 hasConcept C86803240 @default.
• W2035202357 hasConcept C99454951 @default.
• W2035202357 hasConceptScore W2035202357C126322002 @default.
• W2035202357 hasConceptScore W2035202357C134018914 @default.
• W2035202357 hasConceptScore W2035202357C2776607906 @default.
• W2035202357 hasConceptScore W2035202357C2777164284 @default.
• W2035202357 hasConceptScore W2035202357C2777687323 @default.
• W2035202357 hasConceptScore W2035202357C2777902738 @default.
• W2035202357 hasConceptScore W2035202357C2778058571 @default.
• W2035202357 hasConceptScore W2035202357C2779058012 @default.
• W2035202357 hasConceptScore W2035202357C2779076696 @default.
• W2035202357 hasConceptScore W2035202357C2779234561 @default.
• W2035202357 hasConceptScore W2035202357C2779742232 @default.
• W2035202357 hasConceptScore W2035202357C2780186607 @default.
• W2035202357 hasConceptScore W2035202357C2908647359 @default.
• W2035202357 hasConceptScore W2035202357C29456083 @default.
• W2035202357 hasConceptScore W2035202357C2986817661 @default.
• W2035202357 hasConceptScore W2035202357C54355233 @default.
• W2035202357 hasConceptScore W2035202357C57742111 @default.
• W2035202357 hasConceptScore W2035202357C71315377 @default.
• W2035202357 hasConceptScore W2035202357C71924100 @default.
• W2035202357 hasConceptScore W2035202357C86803240 @default.
• W2035202357 hasConceptScore W2035202357C99454951 @default.
• W2035202357 hasIssue "3" @default.
• W2035202357 hasLocation W20352023571 @default.
• W2035202357 hasLocation W20352023572 @default.
• W2035202357 hasOpenAccess W2035202357 @default.
• W2035202357 hasPrimaryLocation W20352023571 @default.
• W2035202357 hasRelatedWork W1974387186 @default.
• W2035202357 hasRelatedWork W2006184025 @default.
• W2035202357 hasRelatedWork W2222968943 @default.

• next