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• W2035207977 abstract "Neuroinflammation, which is one of the hallmarks of neurodegenerative disorders such as Alzheimer's disease, involves secretion of pro-inflammatory mediators by activated glial cells. Secreted phospholipase A2 group IIA (sPLA2IIA) has been implicated as an inflammatory mediator contributing to various peripheral inflammatory conditions; however, little is known about the role this enzyme plays in neuroinflammation. Human microglia-like promonocytic THP-1 cells and human primary astrocytes were used to study sPLA2IIA expression, secretion and function. Production of sPLA2IIA by these cells was induced in response to stimulation by pro-inflammatory mediators at both mRNA and protein levels. Removal of sPLA2IIA from stimulated human microglia-like cell and astrocyte supernatants by immunosorbent caused significant reduction of their toxicity towards SH-SY5Y neuroblastoma cells. Both sPLA2IIA specific and non-specific PLA2 inhibitors exhibited no anti-cytotoxic or neuroprotective effects, suggesting that sPLA2IIA cytotoxicity is mediated by a non-enzymatic mechanism. The data obtained indicate that sPLA2IIA may contribute to the pathogenesis of neurodegenerative diseases involving neuroinflammation. Agents inhibiting the non-enzymatic actions of sPLA2IIA could be used to slow down progression of neurodegenerative processes that are driven by inflammation." @default.
• W2035207977 created "2016-06-24" @default.
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• W2035207977 date "2012-04-01" @default.
• W2035207977 modified "2023-10-18" @default.
• W2035207977 title "Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells" @default.
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• W2035207977 cites W1605460006 @default.
• W2035207977 cites W1617221773 @default.
• W2035207977 cites W1627359200 @default.
• W2035207977 cites W1645987148 @default.
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• W2035207977 doi "https://doi.org/10.1016/j.mcn.2012.02.006" @default.
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