FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035208235> ?p ?o ?g. }

• W2035208235 endingPage "77" @default.
• W2035208235 startingPage "67" @default.
• W2035208235 abstract "Extracellular matrix (ECM) degradation is a hallmark of many chronic inflammatory diseases that can lead to a loss of function, aging, and disease progression. Ultraviolet light (UV) irradiation from the sun is widely considered as the major cause of visible human skin aging, causing increased inflammation and enhanced ECM degradation. Granzyme B (GzmB), a serine protease that is expressed by a variety of cells, accumulates in the extracellular milieu during chronic inflammation and cleaves a number of ECM proteins. We hypothesized that GzmB contributes to ECM degradation in the skin after UV irradiation through both direct cleavage of ECM proteins and indirectly through the induction of other proteinases. Wild-type and GzmB-knockout mice were repeatedly exposed to minimal erythemal doses of solar-simulated UV irradiation for 20 weeks. GzmB expression was significantly increased in wild-type treated skin compared to nonirradiated controls, colocalizing to keratinocytes and to an increased mast cell population. GzmB deficiency significantly protected against the formation of wrinkles and the loss of dermal collagen density, which was related to the cleavage of decorin, an abundant proteoglycan involved in collagen fibrillogenesis and integrity. GzmB also cleaved fibronectin, and GzmB-mediated fibronectin fragments increased the expression of collagen-degrading matrix metalloproteinase-1 (MMP-1) in fibroblasts. Collectively, these findings indicate a significant role for GzmB in ECM degradation that may have implications in many age-related chronic inflammatory diseases." @default.
• W2035208235 created "2016-06-24" @default.
• W2035208235 creator A5003198840 @default.
• W2035208235 creator A5011695124 @default.
• W2035208235 creator A5015532131 @default.
• W2035208235 creator A5018173253 @default.
• W2035208235 creator A5038591200 @default.
• W2035208235 creator A5073375165 @default.
• W2035208235 date "2014-12-11" @default.
• W2035208235 modified "2023-09-30" @default.
• W2035208235 title "Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low‐dose ultraviolet light irradiation" @default.
• W2035208235 cites W1926452350 @default.
• W2035208235 cites W1968796838 @default.
• W2035208235 cites W1979400692 @default.
• W2035208235 cites W1983125814 @default.
• W2035208235 cites W1988007485 @default.
• W2035208235 cites W1988784569 @default.
• W2035208235 cites W1989727926 @default.
• W2035208235 cites W1992131349 @default.
• W2035208235 cites W1997826997 @default.
• W2035208235 cites W1998575976 @default.
• W2035208235 cites W2000506848 @default.
• W2035208235 cites W2004118501 @default.
• W2035208235 cites W2007824685 @default.
• W2035208235 cites W2012110635 @default.
• W2035208235 cites W2012815041 @default.
• W2035208235 cites W2017126827 @default.
• W2035208235 cites W2018436915 @default.
• W2035208235 cites W2021596920 @default.
• W2035208235 cites W2035511138 @default.
• W2035208235 cites W2038705000 @default.
• W2035208235 cites W2050927750 @default.
• W2035208235 cites W2051570308 @default.
• W2035208235 cites W2052949173 @default.
• W2035208235 cites W2055467504 @default.
• W2035208235 cites W2061576158 @default.
• W2035208235 cites W2064817323 @default.
• W2035208235 cites W2064975230 @default.
• W2035208235 cites W2066570934 @default.
• W2035208235 cites W2068986196 @default.
• W2035208235 cites W2070013317 @default.
• W2035208235 cites W2076687077 @default.
• W2035208235 cites W2084751051 @default.
• W2035208235 cites W2087973465 @default.
• W2035208235 cites W2102598791 @default.
• W2035208235 cites W2113185415 @default.
• W2035208235 cites W2140542517 @default.
• W2035208235 cites W2141973975 @default.
• W2035208235 cites W2145386430 @default.
• W2035208235 cites W2160832259 @default.
• W2035208235 cites W2162700552 @default.
• W2035208235 cites W2165790227 @default.
• W2035208235 cites W2313226498 @default.
• W2035208235 cites W4232958984 @default.
• W2035208235 cites W4240037437 @default.
• W2035208235 doi "https://doi.org/10.1111/acel.12298" @default.
• W2035208235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326907" @default.
• W2035208235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25495009" @default.
• W2035208235 hasPublicationYear "2014" @default.
• W2035208235 type Work @default.
• W2035208235 sameAs 2035208235 @default.
• W2035208235 citedByCount "73" @default.
• W2035208235 countsByYear W20352082352015 @default.
• W2035208235 countsByYear W20352082352016 @default.
• W2035208235 countsByYear W20352082352017 @default.
• W2035208235 countsByYear W20352082352018 @default.
• W2035208235 countsByYear W20352082352019 @default.
• W2035208235 countsByYear W20352082352020 @default.
• W2035208235 countsByYear W20352082352021 @default.
• W2035208235 countsByYear W20352082352022 @default.
• W2035208235 countsByYear W20352082352023 @default.
• W2035208235 crossrefType "journal-article" @default.
• W2035208235 hasAuthorship W2035208235A5003198840 @default.
• W2035208235 hasAuthorship W2035208235A5011695124 @default.
• W2035208235 hasAuthorship W2035208235A5015532131 @default.
• W2035208235 hasAuthorship W2035208235A5018173253 @default.
• W2035208235 hasAuthorship W2035208235A5038591200 @default.
• W2035208235 hasAuthorship W2035208235A5073375165 @default.
• W2035208235 hasBestOaLocation W20352082351 @default.
• W2035208235 hasConcept C109523444 @default.
• W2035208235 hasConcept C167672396 @default.
• W2035208235 hasConcept C185592680 @default.
• W2035208235 hasConcept C189165786 @default.
• W2035208235 hasConcept C203014093 @default.
• W2035208235 hasConcept C2776914184 @default.
• W2035208235 hasConcept C2779335624 @default.
• W2035208235 hasConcept C2779794767 @default.
• W2035208235 hasConcept C2780380082 @default.
• W2035208235 hasConcept C2987116853 @default.
• W2035208235 hasConcept C55493867 @default.
• W2035208235 hasConcept C75473681 @default.
• W2035208235 hasConcept C86492073 @default.
• W2035208235 hasConcept C86803240 @default.
• W2035208235 hasConcept C8891405 @default.
• W2035208235 hasConcept C95444343 @default.
• W2035208235 hasConceptScore W2035208235C109523444 @default.
• W2035208235 hasConceptScore W2035208235C167672396 @default.
• W2035208235 hasConceptScore W2035208235C185592680 @default.

• next