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- W2035216589 abstract "Cancer is traditionally viewed as a primarily genetic disorder, however it is now becoming accepted that cancer is also a consequence of abnormal epigenetic events. Genetic changes and aneuploidy are associated with alterations in DNA sequence, and they are a hallmark of the malignant process. Epigenetic alterations are universally present in human cancer and result in heritable changes in gene expression and chromatin structure over many cell generations without changes in DNA sequence, leading to functional consequences equivalent to those induced by genetic alterations. Importantly, intriguing evidence emerged suggesting that epigenetic changes may precede and provoke genetic changes. In this scenario, epigenetic events are primary events while genetic changes (such as mutations) may simply be a consequence of disrupted epigenetic states. This fact may explain why many genetic screens proved to be limited with regard to cancer causality and pathogenesis. Aberrant epigenetic events affect multiple genes and cellular pathways in a non-random fashion and this can predispose to induction and accumulation of genetic changes in the course of tumour initiation and progression. These considerations are critical for a better understanding of tumourigenesis and molecular events underlying the acquisition of drug resistance, as well as development of novel strategies for cancer therapy and prevention." @default.
- W2035216589 created "2016-06-24" @default.
- W2035216589 creator A5007893466 @default.
- W2035216589 creator A5008656366 @default.
- W2035216589 creator A5060871386 @default.
- W2035216589 creator A5083815533 @default.
- W2035216589 date "2008-07-01" @default.
- W2035216589 modified "2023-10-03" @default.
- W2035216589 title "Epigenetic drivers and genetic passengers on the road to cancer" @default.
- W2035216589 cites W144423133 @default.
- W2035216589 cites W1488719611 @default.
- W2035216589 cites W1503892898 @default.
- W2035216589 cites W1504303645 @default.
- W2035216589 cites W1544851750 @default.
- W2035216589 cites W1574725604 @default.
- W2035216589 cites W1639774682 @default.
- W2035216589 cites W1659503129 @default.
- W2035216589 cites W1755052449 @default.
- W2035216589 cites W1967588153 @default.
- W2035216589 cites W1969073965 @default.
- W2035216589 cites W1969438143 @default.
- W2035216589 cites W1974244352 @default.
- W2035216589 cites W1975660840 @default.
- W2035216589 cites W1980802253 @default.
- W2035216589 cites W1984128578 @default.
- W2035216589 cites W1987813113 @default.
- W2035216589 cites W1989116759 @default.
- W2035216589 cites W1990381590 @default.
- W2035216589 cites W1994672948 @default.
- W2035216589 cites W2001602631 @default.
- W2035216589 cites W2002698073 @default.
- W2035216589 cites W2002995168 @default.
- W2035216589 cites W2004172747 @default.
- W2035216589 cites W2005928381 @default.
- W2035216589 cites W2008738118 @default.
- W2035216589 cites W2010677667 @default.
- W2035216589 cites W2011055851 @default.
- W2035216589 cites W2012583042 @default.
- W2035216589 cites W2013756789 @default.
- W2035216589 cites W2014946489 @default.
- W2035216589 cites W2021409968 @default.
- W2035216589 cites W2022439334 @default.
- W2035216589 cites W2023326581 @default.
- W2035216589 cites W2028528554 @default.
- W2035216589 cites W2029197798 @default.
- W2035216589 cites W2029484950 @default.
- W2035216589 cites W2030523067 @default.
- W2035216589 cites W2033141310 @default.
- W2035216589 cites W2034066784 @default.
- W2035216589 cites W2035656617 @default.
- W2035216589 cites W2036256995 @default.
- W2035216589 cites W2036986058 @default.
- W2035216589 cites W2038451572 @default.
- W2035216589 cites W2039067014 @default.
- W2035216589 cites W2040257851 @default.
- W2035216589 cites W2040685858 @default.
- W2035216589 cites W2043033879 @default.
- W2035216589 cites W2044643325 @default.
- W2035216589 cites W2047082908 @default.
- W2035216589 cites W2047529648 @default.
- W2035216589 cites W2047824377 @default.
- W2035216589 cites W2051152566 @default.
- W2035216589 cites W2051966279 @default.
- W2035216589 cites W2054272776 @default.
- W2035216589 cites W2059956556 @default.
- W2035216589 cites W2063517156 @default.
- W2035216589 cites W2068394634 @default.
- W2035216589 cites W2071955851 @default.
- W2035216589 cites W2072063319 @default.
- W2035216589 cites W2072751885 @default.
- W2035216589 cites W2073365346 @default.
- W2035216589 cites W2073552107 @default.
- W2035216589 cites W2074180520 @default.
- W2035216589 cites W2075340488 @default.
- W2035216589 cites W2076845646 @default.
- W2035216589 cites W2081099987 @default.
- W2035216589 cites W2085947779 @default.
- W2035216589 cites W2086046963 @default.
- W2035216589 cites W2086882324 @default.
- W2035216589 cites W2086927107 @default.
- W2035216589 cites W2087182191 @default.
- W2035216589 cites W2087700126 @default.
- W2035216589 cites W2089456325 @default.
- W2035216589 cites W2092118352 @default.
- W2035216589 cites W2099154846 @default.
- W2035216589 cites W2101085659 @default.
- W2035216589 cites W2102653975 @default.
- W2035216589 cites W2103405153 @default.
- W2035216589 cites W2107972234 @default.
- W2035216589 cites W2112224924 @default.
- W2035216589 cites W2115674719 @default.
- W2035216589 cites W2117472174 @default.
- W2035216589 cites W2121417064 @default.
- W2035216589 cites W2123543932 @default.
- W2035216589 cites W2123820544 @default.
- W2035216589 cites W2128985829 @default.
- W2035216589 cites W2135134693 @default.
- W2035216589 cites W2135718122 @default.