FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035221244> ?p ?o ?g. }

• W2035221244 endingPage "214" @default.
• W2035221244 startingPage "208" @default.
• W2035221244 abstract "Abstract The electromyographic (EMG) characteristics of human Duchenne muscular dystrophy (DMD) have been well‐described. However, to our knowledge, no prior needle electromyographic (EMG) studies of motor unit morphology have been undertaken in muscles from the mdx mouse, an animal that is genetically homologous to DMD. There are significant phenotypic differences between the human and murine dystrophic conditions, bringing into question whether the mdx mouse is an appropriate animal model for DMD. This study was done in order to characterize the EMG findings in mdx mice, compared to normal wild‐type mice, and to assess for similarities to DMD. The tibialis anterior and gastrocnemius/soleus muscles from 34 mice (16 C57 wild‐type and 18 mdx ), divided into four age groups (3, 12, 18, and 24 months), were examined. Wild‐type muscles showed normal insertional activity and no abnormal activity at rest. Motor unit action potential (MUAP) parameters were characterized. In contrast to wild‐type muscles, mdx muscles showed increased insertional activity, abnormal spontaneous potentials, and the presence of complex repetitive discharges (CRDs). MUAPs showed increased numbers of phases (4.0 ± 0.6, P < 0.001) and duration (7.1 ± 1.2 ms, P < 0.02), as well as late components (15%). These EMG data indicate that mdx muscles display EMG characteristics similar to those found in muscles from boys with DMD, lending credence to the mdx mouse as an animal model for this disease. The data obtained in this study indicate a potential role for EMG as an in vivo, objective measurement tool that could be used longitudinally to monitor the effects of therapeutic interventions in mdx mice. This is important as there are few objective measures of muscle function in murine models that do not require killing the animal. Muscle Nerve, 2006" @default.
• W2035221244 created "2016-06-24" @default.
• W2035221244 creator A5017030358 @default.
• W2035221244 creator A5019423390 @default.
• W2035221244 creator A5020910026 @default.
• W2035221244 creator A5030862329 @default.
• W2035221244 creator A5043064188 @default.
• W2035221244 creator A5052317872 @default.
• W2035221244 date "2005-11-09" @default.
• W2035221244 modified "2023-10-10" @default.
• W2035221244 title "Electromyographic studies inmdx and wild-type C57 mice" @default.
• W2035221244 cites W1594995535 @default.
• W2035221244 cites W1936471959 @default.
• W2035221244 cites W1963532383 @default.
• W2035221244 cites W1967011351 @default.
• W2035221244 cites W1970848490 @default.
• W2035221244 cites W1972856180 @default.
• W2035221244 cites W1976919537 @default.
• W2035221244 cites W1984433501 @default.
• W2035221244 cites W2001415246 @default.
• W2035221244 cites W2009390107 @default.
• W2035221244 cites W2010762668 @default.
• W2035221244 cites W2019160367 @default.
• W2035221244 cites W2023191886 @default.
• W2035221244 cites W2034598599 @default.
• W2035221244 cites W2035423528 @default.
• W2035221244 cites W2038921430 @default.
• W2035221244 cites W2041890973 @default.
• W2035221244 cites W2044201900 @default.
• W2035221244 cites W2047015778 @default.
• W2035221244 cites W2050825356 @default.
• W2035221244 cites W2061468579 @default.
• W2035221244 cites W2063893684 @default.
• W2035221244 cites W2066180106 @default.
• W2035221244 cites W2070936696 @default.
• W2035221244 cites W2072088562 @default.
• W2035221244 cites W2081550861 @default.
• W2035221244 cites W2089085641 @default.
• W2035221244 cites W2093907840 @default.
• W2035221244 cites W2111051491 @default.
• W2035221244 cites W2112604043 @default.
• W2035221244 cites W2154041187 @default.
• W2035221244 cites W2160251022 @default.
• W2035221244 cites W2284208499 @default.
• W2035221244 cites W2415634287 @default.
• W2035221244 cites W2461137258 @default.
• W2035221244 doi "https://doi.org/10.1002/mus.20455" @default.
• W2035221244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16281275" @default.
• W2035221244 hasPublicationYear "2005" @default.
• W2035221244 type Work @default.
• W2035221244 sameAs 2035221244 @default.
• W2035221244 citedByCount "15" @default.
• W2035221244 countsByYear W20352212442012 @default.
• W2035221244 countsByYear W20352212442013 @default.
• W2035221244 countsByYear W20352212442014 @default.
• W2035221244 countsByYear W20352212442015 @default.
• W2035221244 countsByYear W20352212442016 @default.
• W2035221244 countsByYear W20352212442017 @default.
• W2035221244 countsByYear W20352212442018 @default.
• W2035221244 countsByYear W20352212442020 @default.
• W2035221244 countsByYear W20352212442021 @default.
• W2035221244 crossrefType "journal-article" @default.
• W2035221244 hasAuthorship W2035221244A5017030358 @default.
• W2035221244 hasAuthorship W2035221244A5019423390 @default.
• W2035221244 hasAuthorship W2035221244A5020910026 @default.
• W2035221244 hasAuthorship W2035221244A5030862329 @default.
• W2035221244 hasAuthorship W2035221244A5043064188 @default.
• W2035221244 hasAuthorship W2035221244A5052317872 @default.
• W2035221244 hasConcept C105702510 @default.
• W2035221244 hasConcept C126322002 @default.
• W2035221244 hasConcept C134018914 @default.
• W2035221244 hasConcept C2777515770 @default.
• W2035221244 hasConcept C2778750056 @default.
• W2035221244 hasConcept C2778943923 @default.
• W2035221244 hasConcept C2779030066 @default.
• W2035221244 hasConcept C2780394045 @default.
• W2035221244 hasConcept C2781425072 @default.
• W2035221244 hasConcept C71924100 @default.
• W2035221244 hasConcept C86803240 @default.
• W2035221244 hasConcept C99508421 @default.
• W2035221244 hasConceptScore W2035221244C105702510 @default.
• W2035221244 hasConceptScore W2035221244C126322002 @default.
• W2035221244 hasConceptScore W2035221244C134018914 @default.
• W2035221244 hasConceptScore W2035221244C2777515770 @default.
• W2035221244 hasConceptScore W2035221244C2778750056 @default.
• W2035221244 hasConceptScore W2035221244C2778943923 @default.
• W2035221244 hasConceptScore W2035221244C2779030066 @default.
• W2035221244 hasConceptScore W2035221244C2780394045 @default.
• W2035221244 hasConceptScore W2035221244C2781425072 @default.
• W2035221244 hasConceptScore W2035221244C71924100 @default.
• W2035221244 hasConceptScore W2035221244C86803240 @default.
• W2035221244 hasConceptScore W2035221244C99508421 @default.
• W2035221244 hasIssue "2" @default.
• W2035221244 hasLocation W20352212441 @default.
• W2035221244 hasLocation W20352212442 @default.
• W2035221244 hasOpenAccess W2035221244 @default.
• W2035221244 hasPrimaryLocation W20352212441 @default.
• W2035221244 hasRelatedWork W1577455456 @default.

• next