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- W2035225565 abstract "Abstract Lead represents a significant ecological and public health concern due to its toxicity and its ability to accumulate in living organisms. The present investigation was designated to assess the modulating effect of melatonin (MLT) against lead acetate (LA) genotoxicity. Three cytogenetic end points were considered: the frequencies of micronucleated polychromatic erythrocyte cells (MnPCEs) in the bone marrow, the chromosomal aberration in the primary spermatocytes and the frequency of sperm abnormalities. Male mice were used in this experiment; animals were divided into 8 groups of 6 animals each. First group received an oral gavage of solvent (4% ethanol) and served as control and the other groups received an oral gavage of MLT (10 mg/kg) and/or 10, 50, 100 mg/kg body weight of lead acetate for 11 days. Mice were scarified 24 h after the last treatment. Examination and analysis of MnPCEs and meiotic metaphases showed no mutagenic effect of melatonin. Meanwhile LA induced a significant ( P" @default.
- W2035225565 created "2016-06-24" @default.
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- W2035225565 date "2012-08-01" @default.
- W2035225565 modified "2023-09-23" @default.
- W2035225565 title "The modulating effect of melatonin against the genotoxicity of lead acetate" @default.
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- W2035225565 doi "https://doi.org/10.1016/j.jobaz.2012.07.001" @default.
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