FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035228001> ?p ?o ?g. }

• W2035228001 endingPage "902" @default.
• W2035228001 startingPage "895" @default.
• W2035228001 abstract "Pancreatic cancer is highly resistant to the currently available chemotherapeutic agents. Less than 5% of patients diagnosed with this disease could survive beyond 5 years. Thus, there is an urgent need for the development of novel, efficacious drugs that can treat pancreatic cancer. Herein we report the identification of artesunate (ART), a derivative of artemisinin, as a potent and selective antitumor agent against human pancreatic cancer cells in vitro and in vivo. ART exhibits selective cytotoxic activity against Panc-1, BxPC-3 and CFPAC-1 pancreatic cancer cells with IC50 values that are 2.3- to 24-fold less than that of the normal human hepatic cells (HL-7702). The pan caspase inhibitor zVAD-fmk did not inhibit the cytotoxic activity of ART. Electron microscopy of ART-treated cells revealed severe cytoplasmic swelling and vacuolization, swollen and internally disorganized mitochondria, dilation (but not fragmentation) of the nuclei without chromatin condensation, and cell lysis, yielding a morphotype that is typical of oncosis. The ART-treated cells exhibited a loss of mitochondrial membrane potential (ΔΨm) and ART-induced cell death was inhibited in the presence of the reactive oxygen species (ROS) scavenger N-acetyl-cysteine (NAC). Importantly, ART produced a dose-dependent tumor regression in an in vivo pancreatic cancer xenografts model. The in vivo antitumor activity of ART was similar to that of gemcitabine. Taken together, our study suggests that ART exhibits antitumor activity against human pancreatic cancer via a novel form of oncosis-like cell death, and that ART should be considered a potential therapeutic candidate for treating pancreatic cancer." @default.
• W2035228001 created "2016-06-24" @default.
• W2035228001 creator A5055549554 @default.
• W2035228001 creator A5078337062 @default.
• W2035228001 creator A5081605240 @default.
• W2035228001 creator A5082867442 @default.
• W2035228001 date "2009-08-19" @default.
• W2035228001 modified "2023-10-16" @default.
• W2035228001 title "Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo" @default.
• W2035228001 cites W1966091165 @default.
• W2035228001 cites W1971967721 @default.
• W2035228001 cites W1979129905 @default.
• W2035228001 cites W1979655901 @default.
• W2035228001 cites W1981044029 @default.
• W2035228001 cites W1996907401 @default.
• W2035228001 cites W2012545515 @default.
• W2035228001 cites W2014387796 @default.
• W2035228001 cites W2024217069 @default.
• W2035228001 cites W2054618296 @default.
• W2035228001 cites W2065857667 @default.
• W2035228001 cites W2087402480 @default.
• W2035228001 cites W2090875588 @default.
• W2035228001 cites W2096092730 @default.
• W2035228001 cites W2106917466 @default.
• W2035228001 cites W2108300681 @default.
• W2035228001 cites W2133082107 @default.
• W2035228001 cites W2133669258 @default.
• W2035228001 cites W2142777712 @default.
• W2035228001 cites W2151098840 @default.
• W2035228001 cites W2164959697 @default.
• W2035228001 cites W2166022410 @default.
• W2035228001 cites W4254041232 @default.
• W2035228001 doi "https://doi.org/10.1007/s00280-009-1095-5" @default.
• W2035228001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2824122" @default.
• W2035228001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19690861" @default.
• W2035228001 hasPublicationYear "2009" @default.
• W2035228001 type Work @default.
• W2035228001 sameAs 2035228001 @default.
• W2035228001 citedByCount "134" @default.
• W2035228001 countsByYear W20352280012012 @default.
• W2035228001 countsByYear W20352280012013 @default.
• W2035228001 countsByYear W20352280012014 @default.
• W2035228001 countsByYear W20352280012015 @default.
• W2035228001 countsByYear W20352280012016 @default.
• W2035228001 countsByYear W20352280012017 @default.
• W2035228001 countsByYear W20352280012018 @default.
• W2035228001 countsByYear W20352280012019 @default.
• W2035228001 countsByYear W20352280012020 @default.
• W2035228001 countsByYear W20352280012021 @default.
• W2035228001 countsByYear W20352280012022 @default.
• W2035228001 countsByYear W20352280012023 @default.
• W2035228001 crossrefType "journal-article" @default.
• W2035228001 hasAuthorship W2035228001A5055549554 @default.
• W2035228001 hasAuthorship W2035228001A5078337062 @default.
• W2035228001 hasAuthorship W2035228001A5081605240 @default.
• W2035228001 hasAuthorship W2035228001A5082867442 @default.
• W2035228001 hasBestOaLocation W20352280011 @default.
• W2035228001 hasConcept C121608353 @default.
• W2035228001 hasConcept C126322002 @default.
• W2035228001 hasConcept C142724271 @default.
• W2035228001 hasConcept C150903083 @default.
• W2035228001 hasConcept C154317977 @default.
• W2035228001 hasConcept C185592680 @default.
• W2035228001 hasConcept C190283241 @default.
• W2035228001 hasConcept C202751555 @default.
• W2035228001 hasConcept C207001950 @default.
• W2035228001 hasConcept C2780210213 @default.
• W2035228001 hasConcept C2780258809 @default.
• W2035228001 hasConcept C31573885 @default.
• W2035228001 hasConcept C502942594 @default.
• W2035228001 hasConcept C55493867 @default.
• W2035228001 hasConcept C71924100 @default.
• W2035228001 hasConcept C86803240 @default.
• W2035228001 hasConcept C94030615 @default.
• W2035228001 hasConcept C96232424 @default.
• W2035228001 hasConcept C98274493 @default.
• W2035228001 hasConceptScore W2035228001C121608353 @default.
• W2035228001 hasConceptScore W2035228001C126322002 @default.
• W2035228001 hasConceptScore W2035228001C142724271 @default.
• W2035228001 hasConceptScore W2035228001C150903083 @default.
• W2035228001 hasConceptScore W2035228001C154317977 @default.
• W2035228001 hasConceptScore W2035228001C185592680 @default.
• W2035228001 hasConceptScore W2035228001C190283241 @default.
• W2035228001 hasConceptScore W2035228001C202751555 @default.
• W2035228001 hasConceptScore W2035228001C207001950 @default.
• W2035228001 hasConceptScore W2035228001C2780210213 @default.
• W2035228001 hasConceptScore W2035228001C2780258809 @default.
• W2035228001 hasConceptScore W2035228001C31573885 @default.
• W2035228001 hasConceptScore W2035228001C502942594 @default.
• W2035228001 hasConceptScore W2035228001C55493867 @default.
• W2035228001 hasConceptScore W2035228001C71924100 @default.
• W2035228001 hasConceptScore W2035228001C86803240 @default.
• W2035228001 hasConceptScore W2035228001C94030615 @default.
• W2035228001 hasConceptScore W2035228001C96232424 @default.
• W2035228001 hasConceptScore W2035228001C98274493 @default.
• W2035228001 hasIssue "5" @default.
• W2035228001 hasLocation W20352280011 @default.
• W2035228001 hasLocation W20352280012 @default.

• next