Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035232010> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2035232010 endingPage "474" @default.
- W2035232010 startingPage "467" @default.
- W2035232010 abstract "The effect of long term in vivo administration of IL-4 on the induction of antigen-specific B cells, the splenic microenvironment and the yield of antigen-specific antibody producing hybridomas was studied. Immunization with DNP-KLH, followed by 12 weeks continuous IL-4 treatment resulted in increased numbers of total splenic (non-DNP) IgM and IgG AFC (antibody forming cells) on day 5 after booster, whereas the DNP-specific IgG and IgG1 AFC were reduced compared to age-matched control animals not treated with IL-4. In addition, an almost 300-fold increase in non-DNP IgE was found while the IgE anti-DNP response was minimal. When the splenic cells were used in a fusion protocol, a relative decrease in yield of antigen-specific hybridomas was found in the long term IL-4 treated mice. Immunohistological staining of spleen sections from mice treated with IL-4 up until the time of booster revealed reduced B-cell follicle area and germinal centre numbers. These results show that extensive IL-4 treatment reduced antigen-specific B-cell formation and suggests a reduction in the number of B cells entering the memory B-cell pathway in the spleen." @default.
- W2035232010 created "2016-06-24" @default.
- W2035232010 creator A5006470449 @default.
- W2035232010 creator A5007063744 @default.
- W2035232010 creator A5049142517 @default.
- W2035232010 creator A5056697556 @default.
- W2035232010 creator A5079789734 @default.
- W2035232010 date "1995-05-01" @default.
- W2035232010 modified "2023-09-27" @default.
- W2035232010 title "Impaired Antigen-Specific B-Cell Response and Altered Splenic Microstructure in Mice Following Continuous Administration of IL-4 In Vivo" @default.
- W2035232010 cites W125734413 @default.
- W2035232010 cites W1502659298 @default.
- W2035232010 cites W1515249713 @default.
- W2035232010 cites W1545388095 @default.
- W2035232010 cites W1546288178 @default.
- W2035232010 cites W1565672652 @default.
- W2035232010 cites W1601600505 @default.
- W2035232010 cites W1658684323 @default.
- W2035232010 cites W1972026031 @default.
- W2035232010 cites W1976581960 @default.
- W2035232010 cites W1978411158 @default.
- W2035232010 cites W1982289564 @default.
- W2035232010 cites W1988158037 @default.
- W2035232010 cites W1989741304 @default.
- W2035232010 cites W1996370879 @default.
- W2035232010 cites W2010130789 @default.
- W2035232010 cites W2010290590 @default.
- W2035232010 cites W2020602108 @default.
- W2035232010 cites W2030522563 @default.
- W2035232010 cites W2069784383 @default.
- W2035232010 cites W2072601676 @default.
- W2035232010 cites W2077048475 @default.
- W2035232010 cites W2079363783 @default.
- W2035232010 cites W2118305147 @default.
- W2035232010 cites W2133639395 @default.
- W2035232010 cites W2147715156 @default.
- W2035232010 cites W2156351258 @default.
- W2035232010 cites W2159480334 @default.
- W2035232010 cites W4234705920 @default.
- W2035232010 cites W4242373637 @default.
- W2035232010 doi "https://doi.org/10.1111/j.1365-3083.1995.tb03594.x" @default.
- W2035232010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7725066" @default.
- W2035232010 hasPublicationYear "1995" @default.
- W2035232010 type Work @default.
- W2035232010 sameAs 2035232010 @default.
- W2035232010 citedByCount "2" @default.
- W2035232010 crossrefType "journal-article" @default.
- W2035232010 hasAuthorship W2035232010A5006470449 @default.
- W2035232010 hasAuthorship W2035232010A5007063744 @default.
- W2035232010 hasAuthorship W2035232010A5049142517 @default.
- W2035232010 hasAuthorship W2035232010A5056697556 @default.
- W2035232010 hasAuthorship W2035232010A5079789734 @default.
- W2035232010 hasConcept C141105273 @default.
- W2035232010 hasConcept C147483822 @default.
- W2035232010 hasConcept C150903083 @default.
- W2035232010 hasConcept C153911025 @default.
- W2035232010 hasConcept C159654299 @default.
- W2035232010 hasConcept C185592680 @default.
- W2035232010 hasConcept C203014093 @default.
- W2035232010 hasConcept C207001950 @default.
- W2035232010 hasConcept C2778453870 @default.
- W2035232010 hasConcept C2780931953 @default.
- W2035232010 hasConcept C86803240 @default.
- W2035232010 hasConcept C96926380 @default.
- W2035232010 hasConceptScore W2035232010C141105273 @default.
- W2035232010 hasConceptScore W2035232010C147483822 @default.
- W2035232010 hasConceptScore W2035232010C150903083 @default.
- W2035232010 hasConceptScore W2035232010C153911025 @default.
- W2035232010 hasConceptScore W2035232010C159654299 @default.
- W2035232010 hasConceptScore W2035232010C185592680 @default.
- W2035232010 hasConceptScore W2035232010C203014093 @default.
- W2035232010 hasConceptScore W2035232010C207001950 @default.
- W2035232010 hasConceptScore W2035232010C2778453870 @default.
- W2035232010 hasConceptScore W2035232010C2780931953 @default.
- W2035232010 hasConceptScore W2035232010C86803240 @default.
- W2035232010 hasConceptScore W2035232010C96926380 @default.
- W2035232010 hasIssue "5" @default.
- W2035232010 hasLocation W20352320101 @default.
- W2035232010 hasLocation W20352320102 @default.
- W2035232010 hasOpenAccess W2035232010 @default.
- W2035232010 hasPrimaryLocation W20352320101 @default.
- W2035232010 hasRelatedWork W1975188916 @default.
- W2035232010 hasRelatedWork W2087539308 @default.
- W2035232010 hasRelatedWork W2197013477 @default.
- W2035232010 hasRelatedWork W2256645954 @default.
- W2035232010 hasRelatedWork W3168304835 @default.
- W2035232010 hasRelatedWork W4200418268 @default.
- W2035232010 hasRelatedWork W4206021265 @default.
- W2035232010 hasRelatedWork W4300835294 @default.
- W2035232010 hasRelatedWork W98660436 @default.
- W2035232010 hasRelatedWork W2441589404 @default.
- W2035232010 hasVolume "41" @default.
- W2035232010 isParatext "false" @default.
- W2035232010 isRetracted "false" @default.
- W2035232010 magId "2035232010" @default.
- W2035232010 workType "article" @default.