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- W2035245874 abstract "The water-soluble Pt (II) complex, [PtCl (DMSO)(N4N7-ribavirin)]· H2O (ribavirin is an antiviral drug) has been synthesized and characterized by physico-chemical and spectroscopic methods. The binding interactions of this complex with calf thymus DNA (CT-DNA) were investigated using fluorimetry, spectrophotometry, circular dichroism and viscosimetry. The complex binds to CT-DNA in an intercalative mode. The calculated binding constant, Kb, was 7.2 × 105 M−1. In fluorimetric studies, the enthalpy (ΔH < 0) and entropy (ΔS > 0) changes of the reaction between the Pt (II) complex with CT-DNA showed hydrophobic interaction. In addition, CD study showed stabilization of the right-handed B form of CT-DNA. All these results prove that the complex interacts with CT-DNA via intercalative mode of binding. In comparison with the previous study of the DNA interaction with ribavirin, these results show that platinum complex has greater affinity to CT-DNA." @default.
- W2035245874 created "2016-06-24" @default.
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- W2035245874 date "2012-10-01" @default.
- W2035245874 modified "2023-10-18" @default.
- W2035245874 title "DNA interaction studies of a platinum (II) complex containing an antiviral drug, ribavirin: The effect of metal on DNA binding" @default.
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- W2035245874 doi "https://doi.org/10.1016/j.saa.2012.07.020" @default.
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