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- W2035247332 abstract "Voltage-clamp techniques were used to study the effect of forskolin, 8-Br-cyclic AMP, and phorbol 12,13-dibutyrate (PDBu) on the 3 voltage-dependent calcium current components of mouse dorsal root ganglion neurons in culture. Forskolin and 8-Br-cyclic AMP selectively reduced the transient high-threshold (N-type) calcium current component, an effect also produced by PDBu, a C kinase activator. Pretreatment of cultures with pertussis toxin prevented the reduction of calcium current by PDBu, but was without effect on the reductions produced by forskolin or 8-Br-cyclic AMP. These results support the contention that activation of both A and C kinases selectively affect calcium currents in vertebrate neurons by reducing the N-type calcium current component. While the activation of the C kinase required a G protein to exert its effect, the activation of A kinase did not." @default.
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- W2035247332 date "1988-05-01" @default.
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- W2035247332 title "Reduction of the same calcium current component by A and C kinases: Differential pertussis toxin sensitivity" @default.
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- W2035247332 doi "https://doi.org/10.1016/0304-3940(88)90314-x" @default.
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