FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035248636> ?p ?o ?g. }

• W2035248636 endingPage "569" @default.
• W2035248636 startingPage "561" @default.
• W2035248636 abstract "In this brief review we describe the methods that our group and others have developed in incorporating non-natural amino acids into peptide antigens, principally to increase protease resistance, for potential use in peptide-based vaccines. Peptide-based vaccination has the potential to generate protective immunity without the need for in situ antigen synthesis or further proteolytic processing of the antigen. The ability to deliver minimal T cell epitopes to the effector cells of the immune system also minimises unwanted side effects and simplifies clinical monitoring. The major hurdle in designing successful peptide-based vaccines resides in issues surrounding the delivery and stability of the peptide immunogen, as it is the form in which the epitope is delivered that will determine how it will be processed by the immune system and ultimately whether it will be capable of inducing an appropriate immune response. Thus, one of the confounding issues with peptide-based vaccines is their poor bioavailability, which is predominantly due to proteolysis and oxidative damage of the `naked' peptide. Strategies that stabilise peptide epitopes promise to overcome the current problems and make peptide-based immunogens more applicable in vaccine design." @default.
• W2035248636 created "2016-06-24" @default.
• W2035248636 creator A5059828833 @default.
• W2035248636 creator A5060599347 @default.
• W2035248636 creator A5087347737 @default.
• W2035248636 date "2003-09-01" @default.
• W2035248636 modified "2023-10-17" @default.
• W2035248636 title "Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids" @default.
• W2035248636 cites W142926236 @default.
• W2035248636 cites W1534984779 @default.
• W2035248636 cites W1549752678 @default.
• W2035248636 cites W1554895529 @default.
• W2035248636 cites W1556032813 @default.
• W2035248636 cites W1807410736 @default.
• W2035248636 cites W1965810830 @default.
• W2035248636 cites W1970949598 @default.
• W2035248636 cites W1978541890 @default.
• W2035248636 cites W1980922763 @default.
• W2035248636 cites W2007138438 @default.
• W2035248636 cites W2009881302 @default.
• W2035248636 cites W2010228869 @default.
• W2035248636 cites W2011172759 @default.
• W2035248636 cites W2013324000 @default.
• W2035248636 cites W2020403061 @default.
• W2035248636 cites W2020481425 @default.
• W2035248636 cites W2022316498 @default.
• W2035248636 cites W2028530561 @default.
• W2035248636 cites W2028977956 @default.
• W2035248636 cites W2031281664 @default.
• W2035248636 cites W2032774657 @default.
• W2035248636 cites W2041218370 @default.
• W2035248636 cites W2044215567 @default.
• W2035248636 cites W2045523521 @default.
• W2035248636 cites W2046265343 @default.
• W2035248636 cites W2060122627 @default.
• W2035248636 cites W2061413166 @default.
• W2035248636 cites W2061929014 @default.
• W2035248636 cites W2070181764 @default.
• W2035248636 cites W2070479212 @default.
• W2035248636 cites W2071168946 @default.
• W2035248636 cites W2075908603 @default.
• W2035248636 cites W2079150842 @default.
• W2035248636 cites W2079542677 @default.
• W2035248636 cites W2079892123 @default.
• W2035248636 cites W2084855572 @default.
• W2035248636 cites W2084914681 @default.
• W2035248636 cites W2094026324 @default.
• W2035248636 cites W2097398162 @default.
• W2035248636 cites W2098794031 @default.
• W2035248636 cites W2103647145 @default.
• W2035248636 cites W2103776891 @default.
• W2035248636 cites W2105541213 @default.
• W2035248636 cites W2106955479 @default.
• W2035248636 cites W2110148395 @default.
• W2035248636 cites W2113620373 @default.
• W2035248636 cites W2127525056 @default.
• W2035248636 cites W2131851074 @default.
• W2035248636 cites W2145760895 @default.
• W2035248636 cites W2157270205 @default.
• W2035248636 cites W2157791641 @default.
• W2035248636 cites W2161556416 @default.
• W2035248636 cites W2165142098 @default.
• W2035248636 cites W2917210380 @default.
• W2035248636 doi "https://doi.org/10.1007/bf02442589" @default.
• W2035248636 hasPublicationYear "2003" @default.
• W2035248636 type Work @default.
• W2035248636 sameAs 2035248636 @default.
• W2035248636 citedByCount "7" @default.
• W2035248636 countsByYear W20352486362022 @default.
• W2035248636 crossrefType "journal-article" @default.
• W2035248636 hasAuthorship W2035248636A5059828833 @default.
• W2035248636 hasAuthorship W2035248636A5060599347 @default.
• W2035248636 hasAuthorship W2035248636A5087347737 @default.
• W2035248636 hasBestOaLocation W20352486361 @default.
• W2035248636 hasConcept C147483822 @default.
• W2035248636 hasConcept C159654299 @default.
• W2035248636 hasConcept C181199279 @default.
• W2035248636 hasConcept C185592680 @default.
• W2035248636 hasConcept C195616568 @default.
• W2035248636 hasConcept C203014093 @default.
• W2035248636 hasConcept C2776789287 @default.
• W2035248636 hasConcept C2779281246 @default.
• W2035248636 hasConcept C2779909307 @default.
• W2035248636 hasConcept C2780868878 @default.
• W2035248636 hasConcept C2781307694 @default.
• W2035248636 hasConcept C542903549 @default.
• W2035248636 hasConcept C55493867 @default.
• W2035248636 hasConcept C86803240 @default.
• W2035248636 hasConcept C8891405 @default.
• W2035248636 hasConceptScore W2035248636C147483822 @default.
• W2035248636 hasConceptScore W2035248636C159654299 @default.
• W2035248636 hasConceptScore W2035248636C181199279 @default.
• W2035248636 hasConceptScore W2035248636C185592680 @default.
• W2035248636 hasConceptScore W2035248636C195616568 @default.
• W2035248636 hasConceptScore W2035248636C203014093 @default.
• W2035248636 hasConceptScore W2035248636C2776789287 @default.
• W2035248636 hasConceptScore W2035248636C2779281246 @default.
• W2035248636 hasConceptScore W2035248636C2779909307 @default.

• next