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• W2035261539 endingPage "268" @default.
• W2035261539 startingPage "259" @default.
• W2035261539 abstract "Monocyte-derived cultured dendritic cells (DCs) are potent antigen-presenting cells (APCs) and are susceptible to HIV-1Laiinfection. Compared to the low level of virus production by HIV-1-infected DCs alone, a level of virus two to three orders of magnitude higher was produced by cocultivation of HIV-1-infected DCs with autologous resting CD4+T cells in the presence of a nominal antigen. In this coculture system, direct contact of HIV-1-infected DCs with T cells was crucial for efficient virus transmission and subsequent virus production. Blocking of the LFA-1/ICAM-1 or LFA-3/CD2 interaction between these cells substantially reduced virus production, without influence on IL-2 production by activated T cells. In contrast, cell–cell transmission of HIV between non-APCs and activated T cells was not blocked by an antibody against LFA-3. Since a low level of virus production by HIV-infected DCs was upregulated by cross-linking of CD40, it was suggested that not only focal adhesion, but also mutual activation of HIV-infected DCs and T cells through adhesion molecules, may potentiate virus transmission and production and that such activation signals to HIV may be distinct from signals responsible for IL-2 production in activated T cells." @default.
• W2035261539 created "2016-06-24" @default.
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• W2035261539 date "1997-12-01" @default.
• W2035261539 modified "2023-10-17" @default.
• W2035261539 title "Efficient Virus Transmission from Dendritic Cells to CD4+T Cells in Response to Antigen Depends on Close Contact through Adhesion Molecules" @default.
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• W2035261539 doi "https://doi.org/10.1006/viro.1997.8895" @default.
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