FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035261796> ?p ?o ?g. }

• W2035261796 endingPage "1794" @default.
• W2035261796 startingPage "1783" @default.
• W2035261796 abstract "Effects of cysteine on the pharmacokinetics of clarithromycin were investigated after intravenous administration of the drug at a dose of 20 mg/kg to control rats (4-week fed on 23% casein diet) and rats with PCM (protein-calorie malnutrition, 4-week fed on 5% casein diet) and PCMC (PCM treated with 250 mg/kg for oral cysteine twice daily during the fourth week). Clarithromycin has been reported to be metabolized via hepatic microsomal cytochrome P450 (CYP) 3A4 to 14-hydroxyclarithromycin (primary metabolite of clarithromycin) in human subjects. It has also been reported that in rats with PCM, CYP3A23 level decreased to 40-50% of control level, but decreased CYP3A23 level in rats with PCM completely returned to control level by oral cysteine supplementation (rats with PCMC). Human CYP3A4 and rat CYP3A23 proteins have 73% homology. In rats with PCM, the area under the plasma concentration-time curve from time zero to time infinity, AUC (567, 853 and 558 microg min/ml for control rats and rats with PCM and PCMC, respectively) and percentage of clarithromycin remaining after incubation with liver homogenate (69.6, 83.9 and 71.7%) were significantly greater than those in control rats and rats with PCMC. Moreover, in rats with PCM, the total body clearance, CL (35.3, 23.4 and 35.8 ml/min/kg), nonrenal clearance, CL(NR) (21.3, 15.2 and 24.1 ml/min/kg) and maximum velocity for the disappearance of clarithromycin after incubation with hepatic microsomal fraction, V(max) (351, 211 and 372 pmol/min/mg protein) were significantly slower than those in control rats and rats with PCMC. However, above mentioned each parameter was not significantly different between control rats and rats with PCMC. The above data suggested that metabolism of clarithromycin decreased significantly in rats with PCM as compared to control due to significantly decreased level of CYP3A23 in the rats. By cysteine supplementation (rats with PCMC), some pharmacokinetic parameters of clarithromycin (AUC, CL, CL(NR) and V(max)) were restored fully to control levels because CYP3A23 level was completely returned to control level in rats with PCMC." @default.
• W2035261796 created "2016-06-24" @default.
• W2035261796 creator A5013304410 @default.
• W2035261796 creator A5027012766 @default.
• W2035261796 creator A5028207278 @default.
• W2035261796 creator A5034042915 @default.
• W2035261796 creator A5057447649 @default.
• W2035261796 creator A5066397590 @default.
• W2035261796 creator A5079805084 @default.
• W2035261796 date "2003-08-01" @default.
• W2035261796 modified "2023-10-18" @default.
• W2035261796 title "Effects of cysteine on the pharmacokinetics of intravenous clarithromycin in rats with protein–calorie malnutrition" @default.
• W2035261796 cites W1486157890 @default.
• W2035261796 cites W152943885 @default.
• W2035261796 cites W1775749144 @default.
• W2035261796 cites W1963915050 @default.
• W2035261796 cites W1968559348 @default.
• W2035261796 cites W1984417460 @default.
• W2035261796 cites W1991041819 @default.
• W2035261796 cites W2007970667 @default.
• W2035261796 cites W2034696890 @default.
• W2035261796 cites W2047786986 @default.
• W2035261796 cites W2054979333 @default.
• W2035261796 cites W2057808028 @default.
• W2035261796 cites W2065023395 @default.
• W2035261796 cites W2066806870 @default.
• W2035261796 cites W2068628316 @default.
• W2035261796 cites W2078035407 @default.
• W2035261796 cites W2086684835 @default.
• W2035261796 cites W2139863612 @default.
• W2035261796 cites W2160381299 @default.
• W2035261796 cites W4241791147 @default.
• W2035261796 cites W4244022996 @default.
• W2035261796 cites W973869762 @default.
• W2035261796 doi "https://doi.org/10.1016/s0024-3205(03)00540-x" @default.
• W2035261796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12888117" @default.
• W2035261796 hasPublicationYear "2003" @default.
• W2035261796 type Work @default.
• W2035261796 sameAs 2035261796 @default.
• W2035261796 citedByCount "11" @default.
• W2035261796 countsByYear W20352617962018 @default.
• W2035261796 countsByYear W20352617962020 @default.
• W2035261796 countsByYear W20352617962023 @default.
• W2035261796 crossrefType "journal-article" @default.
• W2035261796 hasAuthorship W2035261796A5013304410 @default.
• W2035261796 hasAuthorship W2035261796A5027012766 @default.
• W2035261796 hasAuthorship W2035261796A5028207278 @default.
• W2035261796 hasAuthorship W2035261796A5034042915 @default.
• W2035261796 hasAuthorship W2035261796A5057447649 @default.
• W2035261796 hasAuthorship W2035261796A5066397590 @default.
• W2035261796 hasAuthorship W2035261796A5079805084 @default.
• W2035261796 hasConcept C109650736 @default.
• W2035261796 hasConcept C112705442 @default.
• W2035261796 hasConcept C11824378 @default.
• W2035261796 hasConcept C126322002 @default.
• W2035261796 hasConcept C134018914 @default.
• W2035261796 hasConcept C181199279 @default.
• W2035261796 hasConcept C185592680 @default.
• W2035261796 hasConcept C2776142715 @default.
• W2035261796 hasConcept C2776962512 @default.
• W2035261796 hasConcept C2777056448 @default.
• W2035261796 hasConcept C2777477808 @default.
• W2035261796 hasConcept C2779201268 @default.
• W2035261796 hasConcept C501593827 @default.
• W2035261796 hasConcept C526171541 @default.
• W2035261796 hasConcept C55493867 @default.
• W2035261796 hasConcept C62231903 @default.
• W2035261796 hasConcept C71924100 @default.
• W2035261796 hasConcept C87644729 @default.
• W2035261796 hasConcept C98274493 @default.
• W2035261796 hasConceptScore W2035261796C109650736 @default.
• W2035261796 hasConceptScore W2035261796C112705442 @default.
• W2035261796 hasConceptScore W2035261796C11824378 @default.
• W2035261796 hasConceptScore W2035261796C126322002 @default.
• W2035261796 hasConceptScore W2035261796C134018914 @default.
• W2035261796 hasConceptScore W2035261796C181199279 @default.
• W2035261796 hasConceptScore W2035261796C185592680 @default.
• W2035261796 hasConceptScore W2035261796C2776142715 @default.
• W2035261796 hasConceptScore W2035261796C2776962512 @default.
• W2035261796 hasConceptScore W2035261796C2777056448 @default.
• W2035261796 hasConceptScore W2035261796C2777477808 @default.
• W2035261796 hasConceptScore W2035261796C2779201268 @default.
• W2035261796 hasConceptScore W2035261796C501593827 @default.
• W2035261796 hasConceptScore W2035261796C526171541 @default.
• W2035261796 hasConceptScore W2035261796C55493867 @default.
• W2035261796 hasConceptScore W2035261796C62231903 @default.
• W2035261796 hasConceptScore W2035261796C71924100 @default.
• W2035261796 hasConceptScore W2035261796C87644729 @default.
• W2035261796 hasConceptScore W2035261796C98274493 @default.
• W2035261796 hasIssue "14" @default.
• W2035261796 hasLocation W20352617961 @default.
• W2035261796 hasLocation W20352617962 @default.
• W2035261796 hasOpenAccess W2035261796 @default.
• W2035261796 hasPrimaryLocation W20352617961 @default.
• W2035261796 hasRelatedWork W1491964893 @default.
• W2035261796 hasRelatedWork W2052588257 @default.
• W2035261796 hasRelatedWork W2065023395 @default.
• W2035261796 hasRelatedWork W2068654339 @default.

• next