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- W2035262988 abstract "Marked interpatient variability in haloperidol (HAL) level-dose (L/D) ratios makes it difficult to use the administered dose for predicting serum concentrations.To investigate the effect of dose, age, total body weight and co-medication on steady-state HAL L/D ratios.Retrospective analysis of dose and HAL blood level data from 168 patients.The HAL L/D ratio decreased curvilinearly with increasing daily dose of HAL. The patients treated with concomitant antiparkinsonian drugs showed a mean HAL L/D ratio that was 24.9% higher than those without antiparkinsonian drugs. The patients treated with concomitant antiepileptic drugs showed a mean HAL L/D ratio that was 27.2% lower than those without antiepileptic drugs. The mean HAL L/D ratio of patients treated with concomitant CYP2D6 substrates was not significantly different from those without CYP2D6 substrates.There is a wide interindividual variability in blood levels of HAL in patients given the same dose. Routine monitoring of HAL serum level is useful, especially in patients who require associated antiepileptic and/or antiparkinsonian medication." @default.
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- W2035262988 date "2003-04-01" @default.
- W2035262988 modified "2023-09-27" @default.
- W2035262988 title "Interindividual variation of serum haloperidol concentrations in Japanese patients - clinical considerations on steady-state serum level-dose ratios" @default.
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- W2035262988 doi "https://doi.org/10.1046/j.1365-2710.2003.00460.x" @default.
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