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- W2035273531 abstract "Ion release from metal implants has been suspected to increase the risk of genotoxic effects in patients wearing orthopedic metal devices. In this study we used urinary 8-hydroxydeoxyguanosine (8-OHdG) as marker of oxidative DNA damage and the frequency of sister chromatid exchanges in lymphocytes to test a possible relationship between the concentrations of chromium or cobalt and the induction of cytogenetic modifications in 46 patients with total hip replacements. A broad range of individual levels of metals has been observed in these patients: chromium in blood, 1.59-14.11 microg/L; chromium in urine, 0.79-93.80 microg/24 h; cobalt in blood, 0.77-37.80 microg/L; cobalt in urine, 2.59-166.94 microg/24 h. By linear regression analysis, no significant correlation between urinary 8OHdG or sister chromatid exchange (SCE) and the concentrations of metals was found. However, cobalt in blood as well as 8-OHdG in urine were higher in patients with implants 3-4 yr old as compared to patients with implants 1-2 yr old. Smoking significantly increased the frequency of SCE. Our data do not indicate a dependence of 8-OHdG in urine or SCE on the levels of chromium or cobalt in patients with total hip replacements." @default.
- W2035273531 created "2016-06-24" @default.
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- W2035273531 date "2002-05-10" @default.
- W2035273531 modified "2023-10-16" @default.
- W2035273531 title "URINARY 8-HYDROXYDEOXYGUANOSINE AND SISTER CHROMATID EXCHANGES IN PATIENTS WITH TOTAL HIP REPLACEMENTS" @default.
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- W2035273531 doi "https://doi.org/10.1080/15287390252900359" @default.
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