FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035275994> ?p ?o ?g. }

• W2035275994 endingPage "2854" @default.
• W2035275994 startingPage "2849" @default.
• W2035275994 abstract "ABSTRACT Although both tetracycline and tigecycline inhibit protein synthesis by sterically hindering the binding of tRNA to the ribosomal A site, tigecycline shows increased efficacy in both in vitro and in vivo activity assays and escapes the most common resistance mechanisms associated with the tetracycline class of antibiotics. These differences in activities are attributed to the tert -butyl-glycylamido side chain found in tigecycline. Our structural analysis by X-ray crystallography shows that tigecycline binds the bacterial 30S ribosomal subunit with its tail in an extended conformation and makes extensive interactions with the 16S rRNA nucleotide C1054. These interactions restrict the mobility of C1054 and contribute to the antimicrobial activity of tigecycline, including its resistance to the ribosomal protection proteins." @default.
• W2035275994 created "2016-06-24" @default.
• W2035275994 creator A5019450584 @default.
• W2035275994 creator A5027081028 @default.
• W2035275994 creator A5032307783 @default.
• W2035275994 creator A5033153369 @default.
• W2035275994 creator A5044352184 @default.
• W2035275994 creator A5054402419 @default.
• W2035275994 creator A5060747407 @default.
• W2035275994 creator A5061265570 @default.
• W2035275994 date "2015-05-01" @default.
• W2035275994 modified "2023-10-16" @default.
• W2035275994 title "Structural Characterization of an Alternative Mode of Tigecycline Binding to the Bacterial Ribosome" @default.
• W2035275994 cites W1969543781 @default.
• W2035275994 cites W2006134342 @default.
• W2035275994 cites W2018562548 @default.
• W2035275994 cites W2020346411 @default.
• W2035275994 cites W2020591349 @default.
• W2035275994 cites W2033273897 @default.
• W2035275994 cites W2045778300 @default.
• W2035275994 cites W2052075229 @default.
• W2035275994 cites W2056589536 @default.
• W2035275994 cites W2076279677 @default.
• W2035275994 cites W2082818874 @default.
• W2035275994 cites W2085941956 @default.
• W2035275994 cites W2092617311 @default.
• W2035275994 cites W2104276827 @default.
• W2035275994 cites W2108921801 @default.
• W2035275994 cites W2113790776 @default.
• W2035275994 cites W2116777154 @default.
• W2035275994 cites W2124433456 @default.
• W2035275994 cites W2128427874 @default.
• W2035275994 cites W2144081223 @default.
• W2035275994 cites W2156918227 @default.
• W2035275994 cites W2163177484 @default.
• W2035275994 cites W2168967909 @default.
• W2035275994 cites W2180229411 @default.
• W2035275994 cites W4248872320 @default.
• W2035275994 doi "https://doi.org/10.1128/aac.04895-14" @default.
• W2035275994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4394779" @default.
• W2035275994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25753625" @default.
• W2035275994 hasPublicationYear "2015" @default.
• W2035275994 type Work @default.
• W2035275994 sameAs 2035275994 @default.
• W2035275994 citedByCount "30" @default.
• W2035275994 countsByYear W20352759942016 @default.
• W2035275994 countsByYear W20352759942017 @default.
• W2035275994 countsByYear W20352759942018 @default.
• W2035275994 countsByYear W20352759942019 @default.
• W2035275994 countsByYear W20352759942020 @default.
• W2035275994 countsByYear W20352759942021 @default.
• W2035275994 countsByYear W20352759942022 @default.
• W2035275994 countsByYear W20352759942023 @default.
• W2035275994 crossrefType "journal-article" @default.
• W2035275994 hasAuthorship W2035275994A5019450584 @default.
• W2035275994 hasAuthorship W2035275994A5027081028 @default.
• W2035275994 hasAuthorship W2035275994A5032307783 @default.
• W2035275994 hasAuthorship W2035275994A5033153369 @default.
• W2035275994 hasAuthorship W2035275994A5044352184 @default.
• W2035275994 hasAuthorship W2035275994A5054402419 @default.
• W2035275994 hasAuthorship W2035275994A5060747407 @default.
• W2035275994 hasAuthorship W2035275994A5061265570 @default.
• W2035275994 hasBestOaLocation W20352759941 @default.
• W2035275994 hasConcept C104317684 @default.
• W2035275994 hasConcept C2777027569 @default.
• W2035275994 hasConcept C2780923616 @default.
• W2035275994 hasConcept C38062823 @default.
• W2035275994 hasConcept C501593827 @default.
• W2035275994 hasConcept C52721335 @default.
• W2035275994 hasConcept C55493867 @default.
• W2035275994 hasConcept C67705224 @default.
• W2035275994 hasConcept C67905577 @default.
• W2035275994 hasConcept C86803240 @default.
• W2035275994 hasConcept C88478588 @default.
• W2035275994 hasConcept C89423630 @default.
• W2035275994 hasConceptScore W2035275994C104317684 @default.
• W2035275994 hasConceptScore W2035275994C2777027569 @default.
• W2035275994 hasConceptScore W2035275994C2780923616 @default.
• W2035275994 hasConceptScore W2035275994C38062823 @default.
• W2035275994 hasConceptScore W2035275994C501593827 @default.
• W2035275994 hasConceptScore W2035275994C52721335 @default.
• W2035275994 hasConceptScore W2035275994C55493867 @default.
• W2035275994 hasConceptScore W2035275994C67705224 @default.
• W2035275994 hasConceptScore W2035275994C67905577 @default.
• W2035275994 hasConceptScore W2035275994C86803240 @default.
• W2035275994 hasConceptScore W2035275994C88478588 @default.
• W2035275994 hasConceptScore W2035275994C89423630 @default.
• W2035275994 hasIssue "5" @default.
• W2035275994 hasLocation W20352759941 @default.
• W2035275994 hasLocation W20352759942 @default.
• W2035275994 hasLocation W20352759943 @default.
• W2035275994 hasLocation W20352759944 @default.
• W2035275994 hasOpenAccess W2035275994 @default.
• W2035275994 hasPrimaryLocation W20352759941 @default.
• W2035275994 hasRelatedWork W1975316249 @default.
• W2035275994 hasRelatedWork W2004346761 @default.
• W2035275994 hasRelatedWork W2020994110 @default.
• W2035275994 hasRelatedWork W2022228485 @default.

• next