Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035280260> ?p ?o ?g. }
- W2035280260 endingPage "631" @default.
- W2035280260 startingPage "621" @default.
- W2035280260 abstract "Genetic analyses aimed at identification of the pathways and downstream effectors of calorie restriction (CR) in the yeast Saccharomyces cerevisiae suggest the importance of central metabolism for the extension of replicative life span by CR. However, the limited gene expression studies to date are not informative, because they have been conducted using cells grown in batch culture which markedly departs from the conditions under which yeasts are grown during life span determinations. In this study, we have examined the gene expression changes that occur during either glucose limitation or elimination of nonessential-amino acids, both of which enhance yeast longevity, culturing cells in a chemostat at equilibrium, which closely mimics conditions they encounter during life span determinations. Expression of 59 genes was examined quantitatively by real-time, reverse transcriptase polymerase chain reaction (qRT-PCR), and the physiological state of the cultures was monitored. Extensive gene expression changes were detected, some of which were common to both CR regimes. The most striking of these was the induction of tricarboxylic acid (TCA) cycle and retrograde response target genes, which appears to be at least partially due to the up-regulation of the HAP4 gene. These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span." @default.
- W2035280260 created "2016-06-24" @default.
- W2035280260 creator A5025480370 @default.
- W2035280260 creator A5035499431 @default.
- W2035280260 creator A5065574010 @default.
- W2035280260 date "2010-08-01" @default.
- W2035280260 modified "2023-10-09" @default.
- W2035280260 title "Gene regulatory changes in yeast during life extension by nutrient limitation" @default.
- W2035280260 cites W1488124756 @default.
- W2035280260 cites W1529654145 @default.
- W2035280260 cites W1583148430 @default.
- W2035280260 cites W1614347411 @default.
- W2035280260 cites W1791126902 @default.
- W2035280260 cites W1879890282 @default.
- W2035280260 cites W1887746592 @default.
- W2035280260 cites W1938310987 @default.
- W2035280260 cites W1962003619 @default.
- W2035280260 cites W1963578989 @default.
- W2035280260 cites W1965253996 @default.
- W2035280260 cites W1965997293 @default.
- W2035280260 cites W1971170967 @default.
- W2035280260 cites W1974238226 @default.
- W2035280260 cites W1977466283 @default.
- W2035280260 cites W1983594275 @default.
- W2035280260 cites W1985233399 @default.
- W2035280260 cites W1985308585 @default.
- W2035280260 cites W1987738803 @default.
- W2035280260 cites W1991087616 @default.
- W2035280260 cites W1994567871 @default.
- W2035280260 cites W1997145913 @default.
- W2035280260 cites W1997183178 @default.
- W2035280260 cites W2004442859 @default.
- W2035280260 cites W2006022142 @default.
- W2035280260 cites W2008619144 @default.
- W2035280260 cites W2008663101 @default.
- W2035280260 cites W2015031589 @default.
- W2035280260 cites W2017147713 @default.
- W2035280260 cites W2025873104 @default.
- W2035280260 cites W2027395393 @default.
- W2035280260 cites W2031823980 @default.
- W2035280260 cites W2043168428 @default.
- W2035280260 cites W2046831727 @default.
- W2035280260 cites W2046989794 @default.
- W2035280260 cites W2051691998 @default.
- W2035280260 cites W2052815426 @default.
- W2035280260 cites W2067395327 @default.
- W2035280260 cites W2068635370 @default.
- W2035280260 cites W2072999507 @default.
- W2035280260 cites W2073414410 @default.
- W2035280260 cites W2074740541 @default.
- W2035280260 cites W2085772485 @default.
- W2035280260 cites W2087801840 @default.
- W2035280260 cites W2097340351 @default.
- W2035280260 cites W2098385754 @default.
- W2035280260 cites W2099371758 @default.
- W2035280260 cites W2102284511 @default.
- W2035280260 cites W2104140801 @default.
- W2035280260 cites W2108836442 @default.
- W2035280260 cites W2112845079 @default.
- W2035280260 cites W2114071827 @default.
- W2035280260 cites W2114721511 @default.
- W2035280260 cites W2115299520 @default.
- W2035280260 cites W2128232312 @default.
- W2035280260 cites W2128387695 @default.
- W2035280260 cites W2135914993 @default.
- W2035280260 cites W2135920982 @default.
- W2035280260 cites W2137828458 @default.
- W2035280260 cites W2143028392 @default.
- W2035280260 cites W2143083347 @default.
- W2035280260 cites W2146264532 @default.
- W2035280260 cites W2147333853 @default.
- W2035280260 cites W2147594695 @default.
- W2035280260 cites W2151258701 @default.
- W2035280260 cites W2157649587 @default.
- W2035280260 cites W2160014215 @default.
- W2035280260 cites W4236709912 @default.
- W2035280260 cites W4239989487 @default.
- W2035280260 cites W4254844148 @default.
- W2035280260 cites W4366807498 @default.
- W2035280260 doi "https://doi.org/10.1016/j.exger.2010.02.008" @default.
- W2035280260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2879456" @default.
- W2035280260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20178842" @default.
- W2035280260 hasPublicationYear "2010" @default.
- W2035280260 type Work @default.
- W2035280260 sameAs 2035280260 @default.
- W2035280260 citedByCount "41" @default.
- W2035280260 countsByYear W20352802602012 @default.
- W2035280260 countsByYear W20352802602013 @default.
- W2035280260 countsByYear W20352802602014 @default.
- W2035280260 countsByYear W20352802602015 @default.
- W2035280260 countsByYear W20352802602016 @default.
- W2035280260 countsByYear W20352802602017 @default.
- W2035280260 countsByYear W20352802602018 @default.
- W2035280260 countsByYear W20352802602019 @default.
- W2035280260 countsByYear W20352802602020 @default.
- W2035280260 countsByYear W20352802602021 @default.
- W2035280260 crossrefType "journal-article" @default.
- W2035280260 hasAuthorship W2035280260A5025480370 @default.