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- W2035291193 abstract "Experimental absence seizures are characterized by the fact that they are exacerbated by both direct and indirect GABA agonists. To date most of the studies that have examined this phenomenon have utilized GABAA agonists. We assessed the effect of a GABAB agonist, baclofen and a specific GABAB antagonist in two pharmacological models of absence seizures in rodent after using either gamma-hydroxybutyrate or pentylenetetrazole to induce the bilaterally synchronous spike wave discharges that typify absence seizures in rodent. Baclofen markedly prolonged and the GABAB antagonist attenuated or blocked the experimental absence seizures in both models. These data suggest a role for GABAB-related mechanisms in the pathogenesis of generalized absence seizures and raise the possibility that GABAB antagonists may have therapeutic potential as antiabsence drugs." @default.
- W2035291193 created "2016-06-24" @default.
- W2035291193 creator A5015390605 @default.
- W2035291193 date "1992-03-01" @default.
- W2035291193 modified "2023-09-24" @default.
- W2035291193 title "Evidence for GABAB-mediated mechanisms in experimental generalized absence seizures" @default.
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- W2035291193 doi "https://doi.org/10.1016/0014-2999(92)90623-c" @default.
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