FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035299023> ?p ?o ?g. }

• W2035299023 endingPage "e70234" @default.
• W2035299023 startingPage "e70234" @default.
• W2035299023 abstract "Loss of large bone segments due to fracture resulting from trauma or tumor removal is a common clinical problem. The goal of this study was to evaluate the use of scaffolds containing testosterone, bone morphogenetic protein-2 (BMP-2), or a combination of both for treatment of critical-size segmental bone defects in mice. A 2.5-mm wide osteotomy was created on the left femur of wildtype and androgen receptor knockout (ARKO) mice. Testosterone, BMP-2, or both were delivered locally using a scaffold that bridged the fracture. Results of X-ray imaging showed that in both wildtype and ARKO mice, BMP-2 treatment induced callus formation within 14 days after initiation of the treatment. Testosterone treatment also induced callus formation within 14 days in wildtype but not in ARKO mice. Micro-computed tomography and histological examinations revealed that testosterone treatment caused similar degrees of callus formation as BMP-2 treatment in wildtype mice, but had no such effect in ARKO mice, suggesting that the androgen receptor is required for testosterone to initiate fracture healing. These results demonstrate that testosterone is as effective as BMP-2 in promoting the healing of critical-size segmental defects and that combination therapy with testosterone and BMP-2 is superior to single therapy. Results of this study may provide a foundation to develop a cost effective and efficient therapeutic modality for treatment of bone fractures with segmental defects." @default.
• W2035299023 created "2016-06-24" @default.
• W2035299023 creator A5002494369 @default.
• W2035299023 creator A5038615752 @default.
• W2035299023 creator A5053297767 @default.
• W2035299023 creator A5057790039 @default.
• W2035299023 creator A5084548945 @default.
• W2035299023 date "2013-08-05" @default.
• W2035299023 modified "2023-09-24" @default.
• W2035299023 title "Testosterone Delivered with a Scaffold Is as Effective as Bone Morphologic Protein-2 in Promoting the Repair of Critical-Size Segmental Defect of Femoral Bone in Mice" @default.
• W2035299023 cites W1507752960 @default.
• W2035299023 cites W1606814949 @default.
• W2035299023 cites W1966976625 @default.
• W2035299023 cites W1967470906 @default.
• W2035299023 cites W1968787705 @default.
• W2035299023 cites W1970467397 @default.
• W2035299023 cites W1971077979 @default.
• W2035299023 cites W1976365868 @default.
• W2035299023 cites W1976820225 @default.
• W2035299023 cites W1980473444 @default.
• W2035299023 cites W1987591238 @default.
• W2035299023 cites W1988552464 @default.
• W2035299023 cites W1991882891 @default.
• W2035299023 cites W1995713263 @default.
• W2035299023 cites W1997113090 @default.
• W2035299023 cites W1998674441 @default.
• W2035299023 cites W2009451706 @default.
• W2035299023 cites W2034478005 @default.
• W2035299023 cites W2034612650 @default.
• W2035299023 cites W2034614189 @default.
• W2035299023 cites W2040244184 @default.
• W2035299023 cites W2040837165 @default.
• W2035299023 cites W2045703870 @default.
• W2035299023 cites W2047018489 @default.
• W2035299023 cites W2062137619 @default.
• W2035299023 cites W2078019962 @default.
• W2035299023 cites W2079562282 @default.
• W2035299023 cites W2090808401 @default.
• W2035299023 cites W2092344861 @default.
• W2035299023 cites W2101625113 @default.
• W2035299023 cites W2105745528 @default.
• W2035299023 cites W2106266873 @default.
• W2035299023 cites W2106580539 @default.
• W2035299023 cites W2111369394 @default.
• W2035299023 cites W2112110048 @default.
• W2035299023 cites W2114448119 @default.
• W2035299023 cites W2123484469 @default.
• W2035299023 cites W2130523127 @default.
• W2035299023 cites W2130635700 @default.
• W2035299023 cites W2131166118 @default.
• W2035299023 cites W2142250806 @default.
• W2035299023 cites W2144924096 @default.
• W2035299023 cites W2154125065 @default.
• W2035299023 cites W2154771084 @default.
• W2035299023 cites W2155046952 @default.
• W2035299023 cites W2156971618 @default.
• W2035299023 cites W2161057551 @default.
• W2035299023 cites W2168905766 @default.
• W2035299023 cites W2171434323 @default.
• W2035299023 cites W2329751560 @default.
• W2035299023 cites W3000473592 @default.
• W2035299023 cites W4319308320 @default.
• W2035299023 cites W76598284 @default.
• W2035299023 doi "https://doi.org/10.1371/journal.pone.0070234" @default.
• W2035299023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733987" @default.
• W2035299023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23940550" @default.
• W2035299023 hasPublicationYear "2013" @default.
• W2035299023 type Work @default.
• W2035299023 sameAs 2035299023 @default.
• W2035299023 citedByCount "22" @default.
• W2035299023 countsByYear W20352990232015 @default.
• W2035299023 countsByYear W20352990232016 @default.
• W2035299023 countsByYear W20352990232018 @default.
• W2035299023 countsByYear W20352990232019 @default.
• W2035299023 countsByYear W20352990232020 @default.
• W2035299023 countsByYear W20352990232022 @default.
• W2035299023 countsByYear W20352990232023 @default.
• W2035299023 crossrefType "journal-article" @default.
• W2035299023 hasAuthorship W2035299023A5002494369 @default.
• W2035299023 hasAuthorship W2035299023A5038615752 @default.
• W2035299023 hasAuthorship W2035299023A5053297767 @default.
• W2035299023 hasAuthorship W2035299023A5057790039 @default.
• W2035299023 hasAuthorship W2035299023A5084548945 @default.
• W2035299023 hasBestOaLocation W20352990231 @default.
• W2035299023 hasConcept C104317684 @default.
• W2035299023 hasConcept C121608353 @default.
• W2035299023 hasConcept C126322002 @default.
• W2035299023 hasConcept C134018914 @default.
• W2035299023 hasConcept C141071460 @default.
• W2035299023 hasConcept C185592680 @default.
• W2035299023 hasConcept C202751555 @default.
• W2035299023 hasConcept C2779279991 @default.
• W2035299023 hasConcept C2780192828 @default.
• W2035299023 hasConcept C30352789 @default.
• W2035299023 hasConcept C31507581 @default.
• W2035299023 hasConcept C55493867 @default.
• W2035299023 hasConcept C61367390 @default.
• W2035299023 hasConcept C71924100 @default.

• next