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- W2035302891 endingPage "1058" @default.
- W2035302891 startingPage "1043" @default.
- W2035302891 abstract "Rho GTPase signaling is altered in human breast tumors, and elevated expression and activation of Rho GTPases correlate with tumor progression, metastasis, and poor prognosis. Here we review the evidence that Rho signaling functions as a key regulator of cell cycle, mitosis, apoptosis, and invasion during breast cancer growth and progression and discuss whether these pleiotropic actions enhance or limit the targetability of this network. We propose that depending on the stage and subtype of breast cancer, targeting Rho signaling may have chemopreventative, anti-tumor, and anti-metastatic efficacy. An understanding of how Rho signaling is perturbed in specific stages and subtypes of breast cancer and how it functions in the context of the complex in vivo environment during the stochastic process of tumor formation and progression are necessary in order to effectively target this signaling network for breast cancer treatment." @default.
- W2035302891 created "2016-06-24" @default.
- W2035302891 creator A5036311933 @default.
- W2035302891 creator A5083096862 @default.
- W2035302891 date "2010-09-01" @default.
- W2035302891 modified "2023-10-16" @default.
- W2035302891 title "Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles Heel for Breast Cancer Treatment?" @default.
- W2035302891 cites W1236053900 @default.
- W2035302891 cites W1519086888 @default.
- W2035302891 cites W1581286771 @default.
- W2035302891 cites W1597258706 @default.
- W2035302891 cites W1597787921 @default.
- W2035302891 cites W1606615500 @default.
- W2035302891 cites W172019621 @default.
- W2035302891 cites W1804236737 @default.
- W2035302891 cites W1850017680 @default.
- W2035302891 cites W1886696076 @default.
- W2035302891 cites W1897509113 @default.
- W2035302891 cites W1903137736 @default.
- W2035302891 cites W1905957625 @default.
- W2035302891 cites W1948700456 @default.
- W2035302891 cites W1965124339 @default.
- W2035302891 cites W1965593148 @default.
- W2035302891 cites W1965837217 @default.
- W2035302891 cites W1966383174 @default.
- W2035302891 cites W1967280935 @default.
- W2035302891 cites W1968044382 @default.
- W2035302891 cites W1969251489 @default.
- W2035302891 cites W1969814333 @default.
- W2035302891 cites W1970319857 @default.
- W2035302891 cites W1971541515 @default.
- W2035302891 cites W1971584907 @default.
- W2035302891 cites W1972363153 @default.
- W2035302891 cites W1972595386 @default.
- W2035302891 cites W1972624153 @default.
- W2035302891 cites W1973228185 @default.
- W2035302891 cites W1975702431 @default.
- W2035302891 cites W1977527355 @default.
- W2035302891 cites W1978465526 @default.
- W2035302891 cites W1978944350 @default.
- W2035302891 cites W1980316109 @default.
- W2035302891 cites W1980751371 @default.
- W2035302891 cites W1981218708 @default.
- W2035302891 cites W1989900133 @default.
- W2035302891 cites W1989979780 @default.
- W2035302891 cites W1990408088 @default.
- W2035302891 cites W1990853543 @default.
- W2035302891 cites W1992546222 @default.
- W2035302891 cites W1995382459 @default.
- W2035302891 cites W1996245793 @default.
- W2035302891 cites W1999088044 @default.
- W2035302891 cites W2001296946 @default.
- W2035302891 cites W2003519013 @default.
- W2035302891 cites W2003889355 @default.
- W2035302891 cites W2004033229 @default.
- W2035302891 cites W2005448885 @default.
- W2035302891 cites W2006860571 @default.
- W2035302891 cites W2008008118 @default.
- W2035302891 cites W2010442546 @default.
- W2035302891 cites W2010779754 @default.
- W2035302891 cites W2012843157 @default.
- W2035302891 cites W2013377296 @default.
- W2035302891 cites W2013576879 @default.
- W2035302891 cites W2014886106 @default.
- W2035302891 cites W2016806028 @default.
- W2035302891 cites W2019785646 @default.
- W2035302891 cites W2021437057 @default.
- W2035302891 cites W2022076650 @default.
- W2035302891 cites W2022816128 @default.
- W2035302891 cites W2023669249 @default.
- W2035302891 cites W2023807898 @default.
- W2035302891 cites W2024281238 @default.
- W2035302891 cites W2024598372 @default.
- W2035302891 cites W2029754521 @default.
- W2035302891 cites W2031951506 @default.
- W2035302891 cites W2032133170 @default.
- W2035302891 cites W2033262816 @default.
- W2035302891 cites W2040210675 @default.
- W2035302891 cites W2040443947 @default.
- W2035302891 cites W2041153640 @default.
- W2035302891 cites W2041779667 @default.
- W2035302891 cites W2041835558 @default.
- W2035302891 cites W2042517746 @default.
- W2035302891 cites W2046966521 @default.
- W2035302891 cites W2049218641 @default.
- W2035302891 cites W2053027820 @default.
- W2035302891 cites W2055498399 @default.
- W2035302891 cites W2055503691 @default.
- W2035302891 cites W2055513686 @default.
- W2035302891 cites W2055545486 @default.
- W2035302891 cites W2057084845 @default.
- W2035302891 cites W2058569850 @default.
- W2035302891 cites W2059166288 @default.
- W2035302891 cites W2059481840 @default.
- W2035302891 cites W2060411924 @default.
- W2035302891 cites W2060630299 @default.
- W2035302891 cites W2062932571 @default.
- W2035302891 cites W2065157632 @default.