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- W2035303744 abstract "Abstract Insulin-resistant adipose and muscle tissues of obese animals are characterized by decreases in insulin sensitivity and responsiveness. The decreased sensitivity is represented only by a shift to the right of the insulin dose-response curve and is due to the observed decrease in the number of insulin receptors of these target tissues. The decreased responsiveness to insulin is manifested by a decrease in the maximal response to even supramaximal concentrations of the hormone. In both adipose and muscle tissues, maximal responses to insulin are achieved with only a minority of receptor sites filled (i.e., they have “spare” receptors). Given that the observed decrease in the number of insulin receptors of insulin-resistant target cells never exceeds that of the “spare” receptors, insulin-resistant adipose and muscle tissues should have enough remaining insulin-binding sites to permit maximal stimulatory effects at maximal insulin concentrations. Consequently, the observed decreased insulin responsiveness of these tissues cannot be attributed to a decreased number of receptors but can be shown to be caused by abnormalities distal to the insulin-receptor interaction. In adipose tissue, distal abnormalities are numerous, although they do not include the glucose transport system per se. In muscle tissue, distal abnormalities are also multiple but do include glucose transport and phosphorylation. Refeeding, fasting, and a high-carbohydrate or a high-fat diet can also be shown to produce metabolic alterations that are distal to the insulin-receptor interaction." @default.
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- W2035303744 title "Postreceptor alterations in the states of insulin resistance" @default.
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- W2035303744 doi "https://doi.org/10.1016/0026-0495(80)90172-9" @default.
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