FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035305204> ?p ?o ?g. }

• W2035305204 endingPage "1346" @default.
• W2035305204 startingPage "1339" @default.
• W2035305204 abstract "Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive. Hypoxia-activated prodrugs such as SN30000 use a mechanism of activation in hypoxic cells similar to that of 2-nitroimidazole hypoxia PET tracers. Therefore, we have evaluated the usefulness of 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-(18)F-pentafluoropropyl)-acetamide ((18)F-EF5) PET to monitor and predict tumor response to SN30000 plus radiation treatment (RT).Human non-small cell lung cancer xenografts (H460) in athymic rats were imaged with (18)F-EF5 PET before and after treatment with SN30000 (90 mg/kg), with or without 15-Gy RT. The feasibility of imaging early changes in hypoxia in response to SN30000 was examined 24 h after treatment, followed by ex vivo γ-counting and immunohistochemical examination to study drug-induced apoptosis. Subsequently, the therapeutic effects of SN30000 with or without RT were evaluated in tumor growth delay studies and compared with early treatment-induced changes observed by (18)F-EF5 PET. Changes in tumor hemoglobin oxygen saturation as a function of time after treatment measured by optical spectroscopy were compared with PET data.The uptake of (18)F-EF5 was significantly lower in SN30000-treated tumors than in saline controls 24 h after treatment (mean standardized uptake value, 0.44 ± 0.08 vs. 0.56 ± 0.08 for control group; P < 0.05). Apoptosis was significantly higher in SN30000-treated tumors than in controls. Early treatment-induced changes in (18)F-EF5 uptake were indicative of tumor response in growth delay studies at the group level. SN30000 plus RT significantly decreased (18)F-EF5 uptake relative to baseline and resulted in complete tumor remission in 5 of 7 animals. SN30000 alone decreased (18)F-EF5 uptake, generally in tumors with high initial standardized uptake values, and showed a minor tumor growth delay effect. The changes induced by SN30000 with or without RT in (18)F-EF5 uptake correlated with baseline hypoxia levels. RT caused significant increases in tumor oxygen concentration and hemoglobin oxygen saturation.A hypoxia PET imaging agent can measure changes in tumor hypoxic fraction in response to SN30000. These results suggest the utility of (18)F-EF5 PET for monitoring early response to tumor treatment with SN30000 plus RT in the clinical development of this novel hypoxia-activated prodrug." @default.
• W2035305204 created "2016-06-24" @default.
• W2035305204 creator A5019181486 @default.
• W2035305204 creator A5045964365 @default.
• W2035305204 creator A5049665116 @default.
• W2035305204 creator A5051030085 @default.
• W2035305204 creator A5056405812 @default.
• W2035305204 creator A5067234230 @default.
• W2035305204 creator A5071519548 @default.
• W2035305204 creator A5078618774 @default.
• W2035305204 creator A5087508568 @default.
• W2035305204 date "2013-06-05" @default.
• W2035305204 modified "2023-10-17" @default.
• W2035305204 title "¹⁸F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model" @default.
• W2035305204 cites W1966709363 @default.
• W2035305204 cites W1982374730 @default.
• W2035305204 cites W1983477402 @default.
• W2035305204 cites W1984943785 @default.
• W2035305204 cites W1988315297 @default.
• W2035305204 cites W1999605661 @default.
• W2035305204 cites W2007287727 @default.
• W2035305204 cites W2011810742 @default.
• W2035305204 cites W2015860044 @default.
• W2035305204 cites W2016861891 @default.
• W2035305204 cites W2024903578 @default.
• W2035305204 cites W2025480263 @default.
• W2035305204 cites W2030009220 @default.
• W2035305204 cites W2089349861 @default.
• W2035305204 cites W2097115941 @default.
• W2035305204 cites W2100782933 @default.
• W2035305204 cites W2110711017 @default.
• W2035305204 cites W2118981922 @default.
• W2035305204 cites W2119554749 @default.
• W2035305204 cites W2124496728 @default.
• W2035305204 cites W2130420198 @default.
• W2035305204 cites W2136348963 @default.
• W2035305204 cites W2136800292 @default.
• W2035305204 cites W2143274699 @default.
• W2035305204 cites W2144287351 @default.
• W2035305204 cites W2147216681 @default.
• W2035305204 cites W2149046406 @default.
• W2035305204 cites W2151469310 @default.
• W2035305204 cites W2154994619 @default.
• W2035305204 cites W3141585456 @default.
• W2035305204 doi "https://doi.org/10.2967/jnumed.112.116293" @default.
• W2035305204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3770943" @default.
• W2035305204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23740105" @default.
• W2035305204 hasPublicationYear "2013" @default.
• W2035305204 type Work @default.
• W2035305204 sameAs 2035305204 @default.
• W2035305204 citedByCount "30" @default.
• W2035305204 countsByYear W20353052042013 @default.
• W2035305204 countsByYear W20353052042014 @default.
• W2035305204 countsByYear W20353052042015 @default.
• W2035305204 countsByYear W20353052042016 @default.
• W2035305204 countsByYear W20353052042017 @default.
• W2035305204 countsByYear W20353052042018 @default.
• W2035305204 countsByYear W20353052042019 @default.
• W2035305204 countsByYear W20353052042020 @default.
• W2035305204 countsByYear W20353052042021 @default.
• W2035305204 countsByYear W20353052042023 @default.
• W2035305204 crossrefType "journal-article" @default.
• W2035305204 hasAuthorship W2035305204A5019181486 @default.
• W2035305204 hasAuthorship W2035305204A5045964365 @default.
• W2035305204 hasAuthorship W2035305204A5049665116 @default.
• W2035305204 hasAuthorship W2035305204A5051030085 @default.
• W2035305204 hasAuthorship W2035305204A5056405812 @default.
• W2035305204 hasAuthorship W2035305204A5067234230 @default.
• W2035305204 hasAuthorship W2035305204A5071519548 @default.
• W2035305204 hasAuthorship W2035305204A5078618774 @default.
• W2035305204 hasAuthorship W2035305204A5087508568 @default.
• W2035305204 hasBestOaLocation W20353052041 @default.
• W2035305204 hasConcept C108215921 @default.
• W2035305204 hasConcept C126322002 @default.
• W2035305204 hasConcept C142724271 @default.
• W2035305204 hasConcept C150903083 @default.
• W2035305204 hasConcept C178790620 @default.
• W2035305204 hasConcept C185592680 @default.
• W2035305204 hasConcept C190283241 @default.
• W2035305204 hasConcept C204232928 @default.
• W2035305204 hasConcept C207001950 @default.
• W2035305204 hasConcept C2776256026 @default.
• W2035305204 hasConcept C2779081379 @default.
• W2035305204 hasConcept C2989005 @default.
• W2035305204 hasConcept C502942594 @default.
• W2035305204 hasConcept C509974204 @default.
• W2035305204 hasConcept C540031477 @default.
• W2035305204 hasConcept C55493867 @default.
• W2035305204 hasConcept C71924100 @default.
• W2035305204 hasConcept C7836513 @default.
• W2035305204 hasConcept C86803240 @default.
• W2035305204 hasConcept C98274493 @default.
• W2035305204 hasConceptScore W2035305204C108215921 @default.
• W2035305204 hasConceptScore W2035305204C126322002 @default.
• W2035305204 hasConceptScore W2035305204C142724271 @default.
• W2035305204 hasConceptScore W2035305204C150903083 @default.
• W2035305204 hasConceptScore W2035305204C178790620 @default.
• W2035305204 hasConceptScore W2035305204C185592680 @default.

• next