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• W2035308972 abstract "The present review update the relationship between acetaldehyde (ACE) and parkinsonism with a specific focus on the role of P450 system and CYP 2E1 isozyme particularly. We have indicated that ACE is able to enhance the parkinsonism induced in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin able to damage the nigrostriatal dopaminergic pathway. Similarly diethyldithiocarbamate, the main metabolite of disulfiram, a drug widely used to control alcoholism, diallylsulfide (DAS) and phenylisothiocyanate also markedly enhance the toxin-related parkinsonism. All these compounds are substrate/inhibitors of CYP450 2E1 isozyme. The presence of CYP 2E1 has been detected in the dopamine (DA) neurons of rodent Substantia Nigra (SN), but a precise function of the enzyme has not been elucidated yet. By treating CYP 2E1 knockout (KO) mice with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, the SN induced lesion was significantly reduced when compared with the lesion observed in wild-type animals. Several in vivo and in vitro studies led to the conclusion that CYP 2E1 may enhance the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice by increasing free radical production inside the dopaminergic neurons. ACE is a good substrate for CYP 2E1 enzyme as the other substrate-inhibitors and by this way may facilitate the susceptibility of dopaminergic neurons to toxic events. The literature suggests that ethanol and/or disulfiram may be responsible for toxic parkinsonism in human and it indicates that basal ganglia are the major targets of disulfiram toxicity. A very recent study reports that there are a decreased methylation of the CYP 2E1 gene and increased expression of CYP 2E1 mRNA in Parkinson's disease (PD) patient brains. This study suggests that epigenetic variants of this cytochrome contribute to the susceptibility, thus confirming multiples lines of evidence which indicate a link between environmental toxins and PD." @default.
• W2035308972 created "2016-06-24" @default.
• W2035308972 creator A5008201472 @default.
• W2035308972 creator A5014163365 @default.
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• W2035308972 creator A5027671121 @default.
• W2035308972 creator A5035880789 @default.
• W2035308972 creator A5080149375 @default.
• W2035308972 creator A5089641976 @default.
• W2035308972 date "2013-01-01" @default.
• W2035308972 modified "2023-09-23" @default.
• W2035308972 title "Acetaldehyde and parkinsonism: role of CYP450 2E1" @default.
• W2035308972 cites W175704563 @default.
• W2035308972 cites W1860140559 @default.
• W2035308972 cites W1892194801 @default.
• W2035308972 cites W1938076507 @default.
• W2035308972 cites W1964220452 @default.
• W2035308972 cites W1968025986 @default.
• W2035308972 cites W1968551244 @default.
• W2035308972 cites W1969800514 @default.
• W2035308972 cites W1976594052 @default.
• W2035308972 cites W1981336339 @default.
• W2035308972 cites W1985968715 @default.
• W2035308972 cites W1991524103 @default.
• W2035308972 cites W1992417826 @default.
• W2035308972 cites W1993253439 @default.
• W2035308972 cites W1993282118 @default.
• W2035308972 cites W1993790483 @default.
• W2035308972 cites W1995006301 @default.
• W2035308972 cites W1995307201 @default.
• W2035308972 cites W1998003169 @default.
• W2035308972 cites W2000066757 @default.
• W2035308972 cites W2002630124 @default.
• W2035308972 cites W2002765333 @default.
• W2035308972 cites W2003972599 @default.
• W2035308972 cites W2004412323 @default.
• W2035308972 cites W2013201944 @default.
• W2035308972 cites W2013407711 @default.
• W2035308972 cites W2014207037 @default.
• W2035308972 cites W2018707557 @default.
• W2035308972 cites W2019121368 @default.
• W2035308972 cites W2022089316 @default.
• W2035308972 cites W2023414515 @default.
• W2035308972 cites W2025540146 @default.
• W2035308972 cites W2026746504 @default.
• W2035308972 cites W2027972413 @default.
• W2035308972 cites W2028605466 @default.
• W2035308972 cites W2030975106 @default.
• W2035308972 cites W2031703663 @default.
• W2035308972 cites W2031736446 @default.
• W2035308972 cites W2033102369 @default.
• W2035308972 cites W2033591080 @default.
• W2035308972 cites W2034494912 @default.
• W2035308972 cites W2036977803 @default.
• W2035308972 cites W2037814086 @default.
• W2035308972 cites W2039347532 @default.
• W2035308972 cites W2042269187 @default.
• W2035308972 cites W2043254435 @default.
• W2035308972 cites W2046344125 @default.
• W2035308972 cites W2048266571 @default.
• W2035308972 cites W2049864364 @default.
• W2035308972 cites W2051940324 @default.
• W2035308972 cites W2052367691 @default.
• W2035308972 cites W2055035870 @default.
• W2035308972 cites W2055173643 @default.
• W2035308972 cites W2058468829 @default.
• W2035308972 cites W2059088884 @default.
• W2035308972 cites W2060644770 @default.
• W2035308972 cites W2060757755 @default.
• W2035308972 cites W2062398703 @default.
• W2035308972 cites W2062872969 @default.
• W2035308972 cites W2063490039 @default.
• W2035308972 cites W2064100139 @default.
• W2035308972 cites W2065911568 @default.
• W2035308972 cites W2067488635 @default.
• W2035308972 cites W2069186900 @default.
• W2035308972 cites W2073090267 @default.
• W2035308972 cites W2076888875 @default.
• W2035308972 cites W2078375609 @default.
• W2035308972 cites W2080496456 @default.
• W2035308972 cites W2082923538 @default.
• W2035308972 cites W2083301389 @default.
• W2035308972 cites W2084983919 @default.
• W2035308972 cites W2085307854 @default.
• W2035308972 cites W2086122328 @default.
• W2035308972 cites W2090286493 @default.
• W2035308972 cites W2090641365 @default.
• W2035308972 cites W2091162455 @default.
• W2035308972 cites W2091205257 @default.
• W2035308972 cites W2095131056 @default.
• W2035308972 cites W2107947237 @default.
• W2035308972 cites W2109529487 @default.
• W2035308972 cites W2114970231 @default.
• W2035308972 cites W2117329421 @default.
• W2035308972 cites W2117996813 @default.
• W2035308972 cites W2121170875 @default.
• W2035308972 cites W2122742102 @default.
• W2035308972 cites W2124345456 @default.
• W2035308972 cites W2125768955 @default.
• W2035308972 cites W2126704418 @default.

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