Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035315033> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2035315033 endingPage "39" @default.
- W2035315033 startingPage "39" @default.
- W2035315033 abstract "Clopidogrel, an irreversible ADP-receptor antagonist, inhibits platelet aggregation mediated by reduced activation of glycoprotein receptor IIb/IIIa. Clopidogrel in combination with aspirin has been shown to be superior to aspirin alone for treating unstable angina, but clopidogrel recipients have shown increases in blood loss, transfusion requirements, and rate of reoperation after cardiac surgery. We describe a patient who had taken clopidogrel 75 mg daily until the day prior to coronary artery bypass graft surgery. Severe postoperative bleeding developed and was refractory to conventional hemostatic therapy consisting of 19 units of packed red blood cell concentrates, 16 of fresh frozen plasma, 8 of platelet apheresis concentrates plus high-dose treatment with aprotinin (500.000 kallikrein-inhibiting units/h) and administration of 0.3 3g/kg 1-deamino-8-D-arginine vasopressin (DDAVP). Two reoperations were performed, but surgical hemostasis was not achieved, so 100 3g/kg recombinant activated factor VII was applied to generate sufficient thrombin to stop the bleeding. This treatment approach reduced the bleeding. Then, to promote clot formation and firmness, 2 g of fibrinogen and 1250 IU of factor XIII were administered, and the bleeding finally stopped. No further transfusions were required, and the patient was discharged from the hospital on day 10 after the operation. This case suggests that in clopidogrel-related bleeding refractory to conventional hemostatic therapy, hemostasis may be achieved by a stepwise administration of coagulation factor concentrates." @default.
- W2035315033 created "2016-06-24" @default.
- W2035315033 creator A5001586855 @default.
- W2035315033 creator A5019432387 @default.
- W2035315033 creator A5022224959 @default.
- W2035315033 creator A5044252740 @default.
- W2035315033 creator A5056482406 @default.
- W2035315033 creator A5083588737 @default.
- W2035315033 date "2005-02-16" @default.
- W2035315033 modified "2023-10-18" @default.
- W2035315033 title "Clopidogrel-Related Refractory Bleeding after Coronary Artery Bypass Graft Surgery: A Rationale for the Use of Coagulation Factor Concentrates?" @default.
- W2035315033 cites W1553345686 @default.
- W2035315033 cites W1680492806 @default.
- W2035315033 cites W2005401250 @default.
- W2035315033 cites W2046936517 @default.
- W2035315033 cites W2064098321 @default.
- W2035315033 cites W2072702070 @default.
- W2035315033 cites W2079234447 @default.
- W2035315033 cites W2087373046 @default.
- W2035315033 cites W2126806823 @default.
- W2035315033 cites W2144746090 @default.
- W2035315033 cites W2149537406 @default.
- W2035315033 doi "https://doi.org/10.1532/hsf98.20041122" @default.
- W2035315033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15769712" @default.
- W2035315033 hasPublicationYear "2005" @default.
- W2035315033 type Work @default.
- W2035315033 sameAs 2035315033 @default.
- W2035315033 citedByCount "17" @default.
- W2035315033 countsByYear W20353150332012 @default.
- W2035315033 countsByYear W20353150332015 @default.
- W2035315033 countsByYear W20353150332022 @default.
- W2035315033 crossrefType "journal-article" @default.
- W2035315033 hasAuthorship W2035315033A5001586855 @default.
- W2035315033 hasAuthorship W2035315033A5019432387 @default.
- W2035315033 hasAuthorship W2035315033A5022224959 @default.
- W2035315033 hasAuthorship W2035315033A5044252740 @default.
- W2035315033 hasAuthorship W2035315033A5056482406 @default.
- W2035315033 hasAuthorship W2035315033A5083588737 @default.
- W2035315033 hasConcept C121332964 @default.
- W2035315033 hasConcept C126322002 @default.
- W2035315033 hasConcept C141071460 @default.
- W2035315033 hasConcept C142424586 @default.
- W2035315033 hasConcept C164705383 @default.
- W2035315033 hasConcept C2776335557 @default.
- W2035315033 hasConcept C2776738589 @default.
- W2035315033 hasConcept C2777292125 @default.
- W2035315033 hasConcept C2777628954 @default.
- W2035315033 hasConcept C2777785093 @default.
- W2035315033 hasConcept C2777849778 @default.
- W2035315033 hasConcept C2778382381 @default.
- W2035315033 hasConcept C2778589496 @default.
- W2035315033 hasConcept C2780400711 @default.
- W2035315033 hasConcept C42219234 @default.
- W2035315033 hasConcept C500558357 @default.
- W2035315033 hasConcept C71924100 @default.
- W2035315033 hasConcept C87355193 @default.
- W2035315033 hasConcept C89560881 @default.
- W2035315033 hasConceptScore W2035315033C121332964 @default.
- W2035315033 hasConceptScore W2035315033C126322002 @default.
- W2035315033 hasConceptScore W2035315033C141071460 @default.
- W2035315033 hasConceptScore W2035315033C142424586 @default.
- W2035315033 hasConceptScore W2035315033C164705383 @default.
- W2035315033 hasConceptScore W2035315033C2776335557 @default.
- W2035315033 hasConceptScore W2035315033C2776738589 @default.
- W2035315033 hasConceptScore W2035315033C2777292125 @default.
- W2035315033 hasConceptScore W2035315033C2777628954 @default.
- W2035315033 hasConceptScore W2035315033C2777785093 @default.
- W2035315033 hasConceptScore W2035315033C2777849778 @default.
- W2035315033 hasConceptScore W2035315033C2778382381 @default.
- W2035315033 hasConceptScore W2035315033C2778589496 @default.
- W2035315033 hasConceptScore W2035315033C2780400711 @default.
- W2035315033 hasConceptScore W2035315033C42219234 @default.
- W2035315033 hasConceptScore W2035315033C500558357 @default.
- W2035315033 hasConceptScore W2035315033C71924100 @default.
- W2035315033 hasConceptScore W2035315033C87355193 @default.
- W2035315033 hasConceptScore W2035315033C89560881 @default.
- W2035315033 hasIssue "1" @default.
- W2035315033 hasLocation W20353150331 @default.
- W2035315033 hasLocation W20353150332 @default.
- W2035315033 hasOpenAccess W2035315033 @default.
- W2035315033 hasPrimaryLocation W20353150331 @default.
- W2035315033 hasRelatedWork W1877581810 @default.
- W2035315033 hasRelatedWork W2066831103 @default.
- W2035315033 hasRelatedWork W2075941057 @default.
- W2035315033 hasRelatedWork W2076238851 @default.
- W2035315033 hasRelatedWork W2171282819 @default.
- W2035315033 hasRelatedWork W2206833555 @default.
- W2035315033 hasRelatedWork W2368367966 @default.
- W2035315033 hasRelatedWork W2391981635 @default.
- W2035315033 hasRelatedWork W3029521642 @default.
- W2035315033 hasRelatedWork W949118015 @default.
- W2035315033 hasVolume "8" @default.
- W2035315033 isParatext "false" @default.
- W2035315033 isRetracted "false" @default.
- W2035315033 magId "2035315033" @default.
- W2035315033 workType "article" @default.