FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035321566> ?p ?o ?g. }

• W2035321566 endingPage "1972" @default.
• W2035321566 startingPage "1966" @default.
• W2035321566 abstract "Objective. To examine differences in genes involved in fat metabolism, energy homeostasis, adipogenesis, and inflammation between endstage and early-stage knee osteoarthritis (OA) infrapatellar fat pads (IFP). Methods. Twenty-nine endstage and 5 early-stage primary OA IFP were harvested at knee surgery. Total RNA was extracted, labeled, and hybridized to whole-genome expression arrays. Unsupervised analysis of all samples using principal components analysis or 2-way hierarchical clustering showed groupings based on tissue source and disease. Statistical testing identified sets of genes that displayed differences between the 2 fat types. Western blot analysis was performed for protein expression of an identified gene of interest. Results. The 29 IFP demonstrated an elevation in the expression of adipokines such as adiponectin and leptin. A statistically significant increased expression was seen for genes of adipogenesis, such as peroxisome proliferator-activated receptor-γ (PPAR-γ), diacylglycerol acyltransferase 2 (DGAT2), cluster of differentiation (CD36), and thyroid hormone responsive spot (THRSP) in the severe OA fat pads as compared to the controls. A subset of 5 patients in the endstage OA group were consistently similar in gene expression to early OA tissue. Protein expression of PPAR-γ2 was 5.4-fold and PPAR-γ1 was 1.4-fold greater in endstage versus early OA tissue. Conclusion. Endstage OA fat pads demonstrated a significant upregulation of genes for fat metabolism and energy homeostasis and a mixed result for inflammatory cytokines." @default.
• W2035321566 created "2016-06-24" @default.
• W2035321566 creator A5027420968 @default.
• W2035321566 creator A5035022718 @default.
• W2035321566 creator A5052742208 @default.
• W2035321566 creator A5064404027 @default.
• W2035321566 creator A5065364916 @default.
• W2035321566 creator A5088099380 @default.
• W2035321566 date "2011-07-15" @default.
• W2035321566 modified "2023-10-18" @default.
• W2035321566 title "Microarray Analysis of the Infrapatellar Fat Pad in Knee Osteoarthritis: Relationship with Joint Inflammation" @default.
• W2035321566 cites W1494472252 @default.
• W2035321566 cites W1504576843 @default.
• W2035321566 cites W1941345530 @default.
• W2035321566 cites W1976621212 @default.
• W2035321566 cites W1978465224 @default.
• W2035321566 cites W1980765804 @default.
• W2035321566 cites W1990692271 @default.
• W2035321566 cites W1990895739 @default.
• W2035321566 cites W2003956312 @default.
• W2035321566 cites W2009524387 @default.
• W2035321566 cites W2009590767 @default.
• W2035321566 cites W2034022269 @default.
• W2035321566 cites W2042134458 @default.
• W2035321566 cites W2046670751 @default.
• W2035321566 cites W2047337561 @default.
• W2035321566 cites W2051051060 @default.
• W2035321566 cites W2055065987 @default.
• W2035321566 cites W2055482229 @default.
• W2035321566 cites W2057491978 @default.
• W2035321566 cites W2066417769 @default.
• W2035321566 cites W2070640588 @default.
• W2035321566 cites W2072733698 @default.
• W2035321566 cites W2078579568 @default.
• W2035321566 cites W2080963235 @default.
• W2035321566 cites W2088820409 @default.
• W2035321566 cites W2093841758 @default.
• W2035321566 cites W2102308673 @default.
• W2035321566 cites W2103352453 @default.
• W2035321566 cites W2104857876 @default.
• W2035321566 cites W2106894846 @default.
• W2035321566 cites W2121555321 @default.
• W2035321566 cites W2138102988 @default.
• W2035321566 cites W2157417440 @default.
• W2035321566 cites W2158079900 @default.
• W2035321566 cites W4243857162 @default.
• W2035321566 cites W4252108671 @default.
• W2035321566 doi "https://doi.org/10.3899/jrheum.101302" @default.
• W2035321566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21765106" @default.
• W2035321566 hasPublicationYear "2011" @default.
• W2035321566 type Work @default.
• W2035321566 sameAs 2035321566 @default.
• W2035321566 citedByCount "58" @default.
• W2035321566 countsByYear W20353215662012 @default.
• W2035321566 countsByYear W20353215662013 @default.
• W2035321566 countsByYear W20353215662014 @default.
• W2035321566 countsByYear W20353215662015 @default.
• W2035321566 countsByYear W20353215662016 @default.
• W2035321566 countsByYear W20353215662017 @default.
• W2035321566 countsByYear W20353215662018 @default.
• W2035321566 countsByYear W20353215662019 @default.
• W2035321566 countsByYear W20353215662020 @default.
• W2035321566 countsByYear W20353215662021 @default.
• W2035321566 countsByYear W20353215662022 @default.
• W2035321566 countsByYear W20353215662023 @default.
• W2035321566 crossrefType "journal-article" @default.
• W2035321566 hasAuthorship W2035321566A5027420968 @default.
• W2035321566 hasAuthorship W2035321566A5035022718 @default.
• W2035321566 hasAuthorship W2035321566A5052742208 @default.
• W2035321566 hasAuthorship W2035321566A5064404027 @default.
• W2035321566 hasAuthorship W2035321566A5065364916 @default.
• W2035321566 hasAuthorship W2035321566A5088099380 @default.
• W2035321566 hasBestOaLocation W20353215661 @default.
• W2035321566 hasConcept C122927707 @default.
• W2035321566 hasConcept C126322002 @default.
• W2035321566 hasConcept C134018914 @default.
• W2035321566 hasConcept C142724271 @default.
• W2035321566 hasConcept C170493617 @default.
• W2035321566 hasConcept C171089720 @default.
• W2035321566 hasConcept C194832188 @default.
• W2035321566 hasConcept C204787440 @default.
• W2035321566 hasConcept C2776164576 @default.
• W2035321566 hasConcept C2776610510 @default.
• W2035321566 hasConcept C2776782570 @default.
• W2035321566 hasConcept C2777391703 @default.
• W2035321566 hasConcept C2779828298 @default.
• W2035321566 hasConcept C2780613262 @default.
• W2035321566 hasConcept C511355011 @default.
• W2035321566 hasConcept C71924100 @default.
• W2035321566 hasConceptScore W2035321566C122927707 @default.
• W2035321566 hasConceptScore W2035321566C126322002 @default.
• W2035321566 hasConceptScore W2035321566C134018914 @default.
• W2035321566 hasConceptScore W2035321566C142724271 @default.
• W2035321566 hasConceptScore W2035321566C170493617 @default.
• W2035321566 hasConceptScore W2035321566C171089720 @default.
• W2035321566 hasConceptScore W2035321566C194832188 @default.
• W2035321566 hasConceptScore W2035321566C204787440 @default.
• W2035321566 hasConceptScore W2035321566C2776164576 @default.

• next