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- W2035330392 abstract "Noninfected and equine herpesvirus type 3 (EHV-3) infected horse embryo dermal fibroblasts (KyED cells) were examined for deoxythymidine kinase (dTK) activity. The activity of extracts from EHV-3-infected KyED cells was approximately seven-fold greater than that of sham-infected cells. Antibody elicited against disrupted EHV-3 infected KyED cells neutralized the EHV-3-induced enzyme activity but not the dTKs present in extracts from uninfected cells. EHV-3 induction of dTK was confirmed by the demonstration of the inability of the virus strain to replicate in the presence of arabinosylthymine (AraT) in cells which themselves were resistant to the drug. In addition, the induced dTK in EHV-3 infected cells was resistant to feedback inhibition by dTTP, but was sensitive to AraT when tested in vitro. This contrasts with the AraT-resistant, dTTP-sensitive enzyme activity observed in extracts of uninfected cells. Electrophoretic analysis of cell extracts in polyacrylamide gels indicated that the EHV-3-induced enzyme comigrates with the host cell cytosol enzyme. These results indicate that infection of cells with EHV-3 results in the induction of a new dTK activity which appears to meet R. A. Jensen's (Annu. Rev. Microbiol.30, 409–425, 1976) criteria for an evolutionary primitive enzyme." @default.
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- W2035330392 date "1980-03-01" @default.
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- W2035330392 title "Deoxythymidine kinase metabolism in equine herpesvirus type 3 infected horse embryo dermal fibroblasts" @default.
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- W2035330392 doi "https://doi.org/10.1016/0042-6822(80)90465-1" @default.
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