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- W2035336651 abstract "To determine the effectiveness of clomiphene citrate (CC) and timed intercourse (TI) in achieving pregnancy in an underserved county population. Retrospective analysis. The medical records of all women who presented to a metropolitan public hospital for infertility between September 2010 and January 2011 and were prescribed CC for ovulation induction or superovulation were analyzed. Data was collected on the 35 women identified including age, body mass index (BMI), infertility diagnosis, day 3 follicle stimulating hormone (FSH) and estradiol (E2) levels, semen analysis, hysterosalpingogram (HSG) results, number of CC cycles, day 21 and 28 progesterone (P4) and BhCG, with pregnancy defined as a positive BhCG. Of the 35 patients, 31 had normal semen analyses and HSGs, and known ovulatory status and BhCG results of at least one cycle. The total number of CC cycles was 86; of these, 58 were ovulatory as defined by P4 > 3 ng/ml and 2 pregnancies were identified. The ovulation rate per CC cycle was 67.4%. The pregnancy rate per ovulatory cycle was 3.45%. The patients were then subdivided by those who always ovulated (16/31); those who sometimes ovulated (6/31); and those who never ovulated (9/31); no significant differences regarding age, day 3 E2 or FSH were found. However, women with a higher BMI and with polycystic ovarian syndrome or oligomenorrhea were less likely to ovulate with CC (P<0.005). The majority of patients ovulated with CC, but few became pregnant. Of the two documented pregnancies, one was an ectopic and the other was lost to follow-up. In this county population, CC and TI alone are not an effective treatment for infertility. Adjuncts, such as dexamethasone or metformin, may increase success in this underserved population." @default.
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- W2035336651 date "2011-09-01" @default.
- W2035336651 modified "2023-09-26" @default.
- W2035336651 title "Success of clomiphene citrate in a county population" @default.
- W2035336651 doi "https://doi.org/10.1016/j.fertnstert.2011.07.966" @default.
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