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- W2035338501 abstract "<h2>Abstract</h2> The contraceptive action of copper IUDs can be improved by the addition of silver or nickel. A clinical study involving 672 women with 6,982 months of use is presented. The pregnancy rates were 0.0% at 12 months of use in 245 women with devices bearing <i>Cu</i> + <i>Ag</i> and <i>Cu</i> + <i>Ni</i>. With <i>Cu</i> alone, the pregnancy rate was 1.5 % and with the same IUD model without metallic adjuncts, 4.4 %. In a control group of 200 women with Lippes C and D, pregnancies occurred in 2.5 % of the cases. First expulsions and removals for bleeding were approximately twice as high as with Lippes, probably due to the design of the device rather than to the metallic action. There were no significant differences as regards the remaining types of event rates. The feasibility of using <i>Cu</i> + <i>Ag</i> and <i>Cu</i> + <i>Ni</i> pairs in a more adequate model of IUD is being discussed. The almost total absence of living sperm in the intrauterine cavity in the presence of metallic IUDs was demonstrated by means of postcoital sperm recovery tests in 76 patients, whilst sperm migration was not affected in the non-metallic models. This might constitute an additional mechanism to explain the excellent effectiveness of metallic IUDs." @default.
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- W2035338501 date "1974-02-01" @default.
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- W2035338501 title "Copper IUD: Enhancement of its efficacy by the addition of silver and nickel" @default.
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- W2035338501 doi "https://doi.org/10.1016/0010-7824(74)90027-4" @default.
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