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- W2035346095 abstract "Unrestrained oncogene activity triggers DNA damage. Cancer cells exploit various stratagems to deal with this potentially lethal event. We found that hematologic cancer cells inactivate the Hippo co-activator Yes-associated protein 1 (YAP1). A synthetic lethal approach is proposed whereby inhibition of the serine/threonine kinase 4 (STK4) could be exploited to restore YAP1 levels in hematologic cancers." @default.
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- W2035346095 date "2014-09-15" @default.
- W2035346095 modified "2023-09-27" @default.
- W2035346095 title "Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers" @default.
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- W2035346095 doi "https://doi.org/10.4161/23723548.2014.970055" @default.
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